B Baier1, P zu Eulenburg, C Geber, F Rohde, R Rolke, C Maihöfner, F Birklein, M Dieterich. 1. Department of Neurology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany; Department of Neurology, German Center for Vertigo and Balance Disorders-IFBLMU, Ludwig-Maximilians-University, Munich, Germany; Munich Center for Systems Neurology (SyNergy), Germany.
Abstract
BACKGROUND: In functional imaging studies, the insular cortex (IC) has been identified as an essential part of the processing of a whole spectrum of multimodal sensory input. However, there are no lesion studies including a sufficient number of patients, which would reinforce the functional imaging data obtained from healthy subjects. Such lesion studies should examine how damage to the IC affects sensory perception. We chose acute stroke patients with lesions affecting the IC in order to fill this gap. METHODS: A comprehensive sensory profiling by applying a quantitative sensory testing protocol was performed and a voxel-lesion behaviour mapping analysis in 24 patients with acute unilateral cortical damage was applied. RESULTS: Our data demonstrate that patients with lesions of the posterior IC have deficits in temperature perception, but did not show other sensory deficits such as hot or cold pain perception associated with specific lesion locations. CONCLUSION: Our data allow the conclusion that the posterior IC may represent the major region responsible for encoding warm and cold perception in the brain. To what extent focal IC lesions may also impair pain processing or induce post-stroke pain has to be addressed in future studies including more patients.
BACKGROUND: In functional imaging studies, the insular cortex (IC) has been identified as an essential part of the processing of a whole spectrum of multimodal sensory input. However, there are no lesion studies including a sufficient number of patients, which would reinforce the functional imaging data obtained from healthy subjects. Such lesion studies should examine how damage to the IC affects sensory perception. We chose acute strokepatients with lesions affecting the IC in order to fill this gap. METHODS: A comprehensive sensory profiling by applying a quantitative sensory testing protocol was performed and a voxel-lesion behaviour mapping analysis in 24 patients with acute unilateral cortical damage was applied. RESULTS: Our data demonstrate that patients with lesions of the posterior IC have deficits in temperature perception, but did not show other sensory deficits such as hot or cold pain perception associated with specific lesion locations. CONCLUSION: Our data allow the conclusion that the posterior IC may represent the major region responsible for encoding warm and cold perception in the brain. To what extent focal IC lesions may also impair pain processing or induce post-stroke pain has to be addressed in future studies including more patients.
Authors: Patrick Beukema; Katherine L Cecil; Elena Peterson; Victor R Mann; Megumi Matsushita; Yoshio Takashima; Saket Navlakha; Alison L Barth Journal: J Comp Neurol Date: 2018-03-25 Impact factor: 3.215
Authors: Sarah Meyer; Simon S Kessner; Bastian Cheng; Marlene Bönstrup; Robert Schulz; Friedhelm C Hummel; Nele De Bruyn; Andre Peeters; Vincent Van Pesch; Thierry Duprez; Stefan Sunaert; Maarten Schrooten; Hilde Feys; Christian Gerloff; Götz Thomalla; Vincent Thijs; Geert Verheyden Journal: Neuroimage Clin Date: 2015-12-11 Impact factor: 4.881
Authors: Justin S Feinstein; Sahib S Khalsa; Tim V Salomons; Kenneth M Prkachin; Laura A Frey-Law; Jennifer E Lee; Daniel Tranel; David Rudrauf Journal: Brain Struct Funct Date: 2015-01-11 Impact factor: 3.270
Authors: Weihong Yuan; Artur Meller; Joshua S Shimony; Tiffany Nash; Blaise V Jones; Scott K Holland; Mekibib Altaye; Holly Barnard; Jannel Phillips; Stephanie Powell; Robert C McKinstry; David D Limbrick; Akila Rajagopal; Francesco T Mangano Journal: Neuroimage Clin Date: 2016-09-04 Impact factor: 4.881