Literature DB >> 24687508

Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy.

Fekade Bruck Sime1, Michael S Roberts2, Morgyn S Warner3, Uwe Hahn4, Thomas A Robertson2, Sue Yeend5, Andy Phay5, Sheila Lehman4, Jeffrey Lipman6, Sandra L Peake7, Jason A Roberts8.   

Abstract

This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and clearance (20.2 ± 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24687508      PMCID： PMC4068433          DOI： 10.1128/AAC.02340-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer.

Authors:  Walter T Hughes; Donald Armstrong; Gerald P Bodey; Eric J Bow; Arthur E Brown; Thierry Calandra; Ronald Feld; Philip A Pizzo; Kenneth V I Rolston; Jerry L Shenep; Lowell S Young
Journal:  Clin Infect Dis       Date:  2002-02-13       Impact factor: 9.079

2.  Augmented renal clearance in the Intensive Care Unit: an illustrative case series.

Authors:  Andrew A Udy; Michael T Putt; Sulochana Shanmugathasan; Jason A Roberts; Jeffrey Lipman
Journal:  Int J Antimicrob Agents       Date:  2010-03-21       Impact factor: 5.283

3.  Very high GFR in cancer patients undergoing chemotherapy: prevalence, carboplatin dosing patterns and chemotherapy toxicity.

Authors:  Amitesh Chandra Roy; David Neil Jones; John P Slavotinek; Ganessan Kichenadasse; Chris Karapetis; Earl Lam; Sarwan Bishnoi; Bogda Koczwara
Journal:  Asia Pac J Clin Oncol       Date:  2011-09       Impact factor: 2.601

4.  Pharmacokinetics of meropenem in febrile neutropenic patients. Swedish study group.

Authors:  A Nyhlén; B Ljungberg; I Nilsson-Ehle
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-11       Impact factor: 3.267

Review 5.  Infusional β-lactam antibiotics in febrile neutropenia: has the time come?

Authors:  Iain J Abbott; Jason A Roberts
Journal:  Curr Opin Infect Dis       Date:  2012-12       Impact factor: 4.915

6.  Antibiotic therapy of infections due to Pseudomonas aeruginosa in normal and granulocytopenic mice: comparison of murine and human pharmacokinetics.

Authors:  A U Gerber; H P Brugger; C Feller; T Stritzko; B Stalder
Journal:  J Infect Dis       Date:  1986-01       Impact factor: 5.226

Review 7.  Treatment of acute renal failure.

Authors:  R A Star
Journal:  Kidney Int       Date:  1998-12       Impact factor: 10.612

8.  Moxalactam and piperacillin: a study of in vitro characteristics and pharmacokinetics in cancer patients.

Authors:  G L Drusano; C de Jongh; K Newman; J Joshi; R Wharton; M R Moody; S C Schimpff
Journal:  Infection       Date:  1985 Jan-Feb       Impact factor: 3.553

Review 9.  Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins.

Authors:  W A Craig
Journal:  Diagn Microbiol Infect Dis       Date:  1995 May-Jun       Impact factor: 2.803

10.  Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.

Authors:  David F Gaieski; Mark E Mikkelsen; Roger A Band; Jesse M Pines; Richard Massone; Frances F Furia; Frances S Shofer; Munish Goyal
Journal:  Crit Care Med       Date:  2010-04       Impact factor: 7.598
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  10 in total

1.  Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia.

Authors:  Fekade Bruck Sime; Uwe Hahn; Morgyn S Warner; Ing Soo Tiong; Michael S Roberts; Jeffrey Lipman; Sandra L Peake; Jason A Roberts
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

2.  Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age.

Authors:  Dagan O Lonsdale; Emma H Baker; Karin Kipper; Charlotte Barker; Barbara Philips; Andrew Rhodes; Mike Sharland; Joseph F Standing
Journal:  Br J Clin Pharmacol       Date:  2018-11-26       Impact factor: 4.335

3.  Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools.

Authors:  Ferdinand Anton Weinelt; Miriam Songa Stegemann; Anja Theloe; Frieder Pfäfflin; Stephan Achterberg; Franz Weber; Lucas Dübel; Agata Mikolajewska; Alexander Uhrig; Peggy Kiessling; Wilhelm Huisinga; Robin Michelet; Stefanie Hennig; Charlotte Kloft
Journal:  Antibiotics (Basel)       Date:  2022-06-02

4.  Measurement of piperacillin plasma concentrations in cancer patients with suspected infection.

Authors:  Tobias Rachow; Verena Schlüter; Sibylle Bremer-Streck; Udo Lindig; Sebastian Scholl; Peter Schlattmann; Michael Kiehntopf; Andreas Hochhaus; Marie von Lilienfeld-Toal
Journal:  Infection       Date:  2017-05-17       Impact factor: 3.553

5.  Vancomycin dosing in neutropenic patients.

Authors:  Michiel B Haeseker; Sander Croes; Cees Neef; Cathrien A Bruggeman; Leo M L Stolk; Annelies Verbon
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

6.  Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy: the impact of body weight and target on an optimal dosing regimen.

Authors:  Anders Thorsted; Anders N Kristoffersson; Sabine F Maarbjerg; Henrik Schrøder; Mikala Wang; Birgitte Brock; Elisabet I Nielsen; Lena E Friberg
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

7.  Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand.

Authors:  Kittiya Jantarathaneewat; Anucha Apisarnthanarak; Wasithep Limvorapitak; David J Weber; Preecha Montakantikul
Journal:  Antibiotics (Basel)       Date:  2021-04-17

8.  Continuous infusion of piperacillin-tazobactam significantly improves target attainment in children with cancer and fever.

Authors:  Sabine F Maarbjerg; Anders Thorsted; Lena E Friberg; Elisabet I Nielsen; Mikala Wang; Henrik Schrøder; Birgitte K Albertsen
Journal:  Cancer Rep (Hoboken)       Date:  2021-11-18

9.  Piperacillin concentration in relation to therapeutic range in critically ill patients--a prospective observational study.

Authors:  Johannes Zander; Gundula Döbbeler; Dorothea Nagel; Barbara Maier; Christina Scharf; Mikayil Huseyn-Zada; Jette Jung; Lorenz Frey; Michael Vogeser; Michael Zoller
Journal:  Crit Care       Date:  2016-04-04       Impact factor: 9.097

Review 10.  Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients.

Authors:  Rui Pedro Veiga; José-Artur Paiva
Journal:  Crit Care       Date:  2018-09-24       Impact factor: 9.097
  10 in total

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