Literature DB >> 24687500

Deoxysugars as antituberculars and alpha-mannosidase inhibitors.

Vivek Kashyap1, Smriti Sharma2, Vinayak Singh1, Sandeep K Sharma1, Mohammad Saquib2, Ranjana Srivastava3, Arun K Shaw4.   

Abstract

A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a competitive inhibitor with a Ki value of 353.9 μM.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24687500      PMCID： PMC4068473          DOI： 10.1128/AAC.02715-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Carbohydrate-Based Antibiotics: A New Approach to Tackling the Problem of Resistance.

Authors:  Thomas K. Ritter; Chi-Huey Wong
Journal:  Angew Chem Int Ed Engl       Date:  2001-10-01       Impact factor: 15.336

Review 2.  Global tuberculosis drug development pipeline: the need and the reality.

Authors:  Zhenkun Ma; Christian Lienhardt; Helen McIlleron; Andrew J Nunn; Xiexiu Wang
Journal:  Lancet       Date:  2010-05-18       Impact factor: 79.321

3.  2,3-dideoxy hex-2-enopyranosid-4-uloses as promising new anti-tubercular agents: design, synthesis, biological evaluation and SAR studies.

Authors:  Mohammad Saquib; Irfan Husain; Smriti Sharma; Garima Yadav; Vipul K Singh; Sandeep K Sharma; Priyanka Shah; Mohammad Imran Siddiqi; Brijesh Kumar; Jawahar Lal; Girish K Jain; Brahm S Srivastava; Ranjana Srivastava; Arun K Shaw
Journal:  Eur J Med Chem       Date:  2011-03-08       Impact factor: 6.514

Review 4.  Carbohydrates as scaffolds in drug discovery.

Authors:  Wim Meutermans; Giang Thanh Le; Bernd Becker
Journal:  ChemMedChem       Date:  2006-11       Impact factor: 3.466

Review 5.  Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.

Authors:  Jordi B Torrelles; Larry S Schlesinger
Journal:  Tuberculosis (Edinb)       Date:  2010-03-03       Impact factor: 3.131

6.  Synthesis and biological evaluation of trans 6-methoxy-1,1-dimethyl-2-phenyl-3-aryl-2,3-dihydro-1H-inden-4-yloxyalkylamine derivatives against drug susceptible, non-replicating M. tuberculosis H37Rv and clinical multidrug resistant strains.

Authors:  Shailesh Kumar; Atma P Dwivedi; Vivek Kr Kashyap; A K Saxena; A K Dwivedi; Ranjana Srivastava; Devi P Sahu
Journal:  Bioorg Med Chem Lett       Date:  2013-02-15       Impact factor: 2.823

Review 7.  Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections.

Authors:  G A Pankey; L D Sabath
Journal:  Clin Infect Dis       Date:  2004-03-01       Impact factor: 9.079

8.  Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds.

Authors:  B E Maryanoff; S O Nortey; J F Gardocki; R P Shank; S P Dodgson
Journal:  J Med Chem       Date:  1987-05       Impact factor: 7.446

9.  C-3 alkyl/arylalkyl-2,3-dideoxy hex-2-enopyranosides as antitubercular agents: synthesis, biological evaluation, and QSAR study.

Authors:  Mohammad Saquib; Manish K Gupta; Ram Sagar; Yenamandra S Prabhakar; Arun K Shaw; Rishi Kumar; Prakas R Maulik; Anil N Gaikwad; Sudhir Sinha; Anil K Srivastava; Vinita Chaturvedi; Ranjana Srivastava; Brahm S Srivastava
Journal:  J Med Chem       Date:  2007-06-02       Impact factor: 7.446

10.  The alpha(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120.

Authors:  Jan Balzarini
Journal:  FEBS Lett       Date:  2007-04-25       Impact factor: 4.124
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.