Literature DB >> 2468604

Human monocyte activation induced by an anti-CD14 monoclonal antibody.

C Schütt1, B Ringel, M Nausch, V Bazil, V Horejsí, P Neels, H Walzel, L Jonas, E Siegl, H Friemel.   

Abstract

An anti-CD14 mAb RoMo-1 rapidly induces in human monocytes a transient oxidative burst activity as detected by chemiluminescence assay. Pretreatment of these cells with the mAb markedly suppresses the monocyte chemiluminescence response to opsonized zymosan. In addition, the antibody induces a significant increase of IL-1 production and secretion by mononuclear cells, comparable to a similar effect of rIFN-gamma or LPS. Electron microscopy demonstrates internalization of the CD14 molecules after interaction with the mAb in a characteristic receptor-like manner.

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Year:  1988        PMID： 2468604     DOI： 10.1016/0165-2478(88)90162-9

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  12 in total

1.  Expression of adhesion molecules on granulocytes and monocytes from patients with asthma stimulated in vitro with interleukin-8 and monocyte chemotactic protein-1.

Authors:  E M Verdegaal; S T Zegveld; I Blokland; H Beekhuizen; W Bakker; L N Willems; R van Furth
Journal:  Inflammation       Date:  1998-04       Impact factor: 4.092

2.  Serum CD14 levels in polytraumatized and severely burned patients.

Authors:  C Krüger; C Schütt; U Obertacke; T Joka; F E Müller; J Knöller; M Köller; W König; W Schönfeld
Journal:  Clin Exp Immunol       Date:  1991-08       Impact factor: 4.330

Review 3.  The role of CD14 and lipopolysaccharide-binding protein (LBP) in the activation of different cell types by endotoxin.

Authors:  R R Schumann; E T Rietschel; H Loppnow
Journal:  Med Microbiol Immunol       Date:  1994-12       Impact factor: 3.402

4.  Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway.

Authors:  R L Kitchens; R J Ulevitch; R S Munford
Journal:  J Exp Med       Date:  1992-08-01       Impact factor: 14.307

5.  Acute effects of smoking and high experimental exposure to environmental tobacco smoke (ETS) on the immune system.

Authors:  S Hockertz; A Emmendörffer; G Scherer; T Ruppert; H Daube; A R Tricker; F Adlkofer
Journal:  Cell Biol Toxicol       Date:  1994-06       Impact factor: 6.691

6.  Evaluation of soluble CD 14 and neopterin as serum parameters of the inflammatory activity of pulmonary sarcoidosis.

Authors:  J Homolka; J Lorenz; H D Zuchold; J Müller-Quernheim
Journal:  Clin Investig       Date:  1992-10

7.  Modulation of endotoxin-induced monokine release in human monocytes by lipid A partial structures that inhibit binding of 125I-lipopolysaccharide.

Authors:  A J Ulmer; W Feist; H Heine; T Kirikae; F Kirikae; S Kusumoto; T Kusama; H Brade; U Schade; E T Rietschel
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

8.  CD14 is involved in control of human immunodeficiency virus type 1 expression in latently infected cells by lipopolysaccharide.

Authors:  O Bagasra; S D Wright; T Seshamma; J W Oakes; R J Pomerantz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

9.  Molecular analysis of highly enriched populations of T-cell-depleted monocytes.

Authors:  L F Aleixo; M M Goodenow; J W Sleasman
Journal:  Clin Diagn Lab Immunol       Date:  1995-11

Review 10.  T-lymphocytes and monocytes in atherogenesis.

Authors:  G Schmitz; A S Herr; G Rothe
Journal:  Herz       Date:  1998-05       Impact factor: 1.443
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