Literature DB >> 24685331

Exome array study did not identify novel variants in Alzheimer's disease.

Sun Ju Chung1, Mi-Jung Kim2, Juyeon Kim3, Young Jin Kim3, Sooyeoun You4, Jaeyoung Koh3, Seong Yoon Kim5, Jae-Hong Lee3.   

Abstract

Genetic variants so far identified explain a small fraction of the overall inherited risk of Alzheimer's disease (AD). We aimed to identify novel genetic variants in AD using exome array that contains comprehensive panel. We genotyped 295,988 variants in 1005 subjects (400 AD cases and 605 controls) using Axiom Exome Genotyping Array that contains a pool of variants discovered in over 16 major human exome sequencing initiatives. Logistic regression analysis and the sequence kernel association optimal test were performed. The APOE, APOC1, and TOMM40 showed significant associations with AD in the single variant analysis. However, no significant association of other variants with AD was observed. This exome array study failed to identify novel genetic variants in AD.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  APOC1; APOE; Alzheimer's disease; Exome array; TOMM40

Mesh：

Substances：

Year:  2014        PMID： 24685331     DOI： 10.1016/j.neurobiolaging.2014.03.007

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  12 in total

1.  A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

Authors:  Jason A Chen; Qing Wang; Jeremy Davis-Turak; Yun Li; Anna M Karydas; Sandy C Hsu; Renee L Sears; Doxa Chatzopoulou; Alden Y Huang; Kevin J Wojta; Eric Klein; Jason Lee; Duane L Beekly; Adam Boxer; Kelley M Faber; Claudia M Haase; Josh Miller; Wayne W Poon; Ami Rosen; Howard Rosen; Anna Sapozhnikova; Jill Shapira; Arousiak Varpetian; Tatiana M Foroud; Robert W Levenson; Allan I Levey; Walter A Kukull; Mario F Mendez; John Ringman; Helena Chui; Carl Cotman; Charles DeCarli; Bruce L Miller; Daniel H Geschwind; Giovanni Coppola
Journal:  JAMA Neurol       Date:  2015-04       Impact factor: 18.302

2.  Genetic Analysis of TREM2 Variants in Tunisian Patients with Alzheimer's Disease.

Authors:  Zied Landoulsi; Mouna Ben Djebara; Imen Kacem; Youssef Sidhom; Rym Kefi; Sonia Abdelhak; Amina Gargouri-Berrechid; Riadh Gouider
Journal:  Med Princ Pract       Date:  2018-05-03       Impact factor: 1.927

Review 3.  Genomic variants, genes, and pathways of Alzheimer's disease: An overview.

Authors:  Adam C Naj; Gerard D Schellenberg
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2017-01       Impact factor: 3.568

4.  Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.

Authors:  Jennifer B Permuth; Ailith Pirie; Y Ann Chen; Hui-Yi Lin; Brett M Reid; Zhihua Chen; Alvaro Monteiro; Joe Dennis; Gustavo Mendoza-Fandino; Hoda Anton-Culver; Elisa V Bandera; Maria Bisogna; Louise Brinton; Angela Brooks-Wilson; Michael E Carney; Georgia Chenevix-Trench; Linda S Cook; Daniel W Cramer; Julie M Cunningham; Cezary Cybulski; Aimee A D'Aloisio; Jennifer Anne Doherty; Madalene Earp; Robert P Edwards; Brooke L Fridley; Simon A Gayther; Aleksandra Gentry-Maharaj; Marc T Goodman; Jacek Gronwald; Estrid Hogdall; Edwin S Iversen; Anna Jakubowska; Allan Jensen; Beth Y Karlan; Linda E Kelemen; Suzanne K Kjaer; Peter Kraft; Nhu D Le; Douglas A Levine; Jolanta Lissowska; Jan Lubinski; Keitaro Matsuo; Usha Menon; Rosemary Modugno; Kirsten B Moysich; Toru Nakanishi; Roberta B Ness; Sara Olson; Irene Orlow; Celeste L Pearce; Tanja Pejovic; Elizabeth M Poole; Susan J Ramus; Mary Anne Rossing; Dale P Sandler; Xiao-Ou Shu; Honglin Song; Jack A Taylor; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Shelley S Tworoger; Penelope M Webb; Nicolas Wentzensen; Lynne R Wilkens; Stacey Winham; Yin-Ling Woo; Anna H Wu; Hannah Yang; Wei Zheng; Argyrios Ziogas; Catherine M Phelan; Joellen M Schildkraut; Andrew Berchuck; Ellen L Goode; Paul D P Pharoah; Thomas A Sellers
Journal:  Hum Mol Genet       Date:  2016-07-04       Impact factor: 6.150

5.  Assessing the Power of Exome Chips.

Authors:  Christian Magnus Page; Sergio E Baranzini; Bjørn-Helge Mevik; Steffan Daniel Bos; Hanne F Harbo; Bettina Kulle Andreassen
Journal:  PLoS One       Date:  2015-10-05       Impact factor: 3.240

Review 6.  Identification of rare variants in Alzheimer's disease.

Authors:  Jenny Lord; Alexander J Lu; Carlos Cruchaga
Journal:  Front Genet       Date:  2014-10-28       Impact factor: 4.599

Review 7.  TREM2 regulates innate immunity in Alzheimer's disease.

Authors:  Jiang-Tao Li; Ying Zhang
Journal:  J Neuroinflammation       Date:  2018-04-14       Impact factor: 8.322

8.  Differential role of triggering receptors expressed on myeloid cells 2 R47H in 3 neurodegenerative diseases based on a systematic review and meta-analysis.

Authors:  Bin Zhang; Rui Li; Yufan Zhang; Xia Gao
Journal:  Medicine (Baltimore)       Date:  2020-01       Impact factor: 1.889

Review 9.  Additional mechanisms conferring genetic susceptibility to Alzheimer's disease.

Authors:  Miguel Calero; Alberto Gómez-Ramos; Olga Calero; Eduardo Soriano; Jesús Avila; Miguel Medina
Journal:  Front Cell Neurosci       Date:  2015-04-09       Impact factor: 5.505

10.  Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.

Authors:  Xiaopu Zhou; Yu Chen; Fanny C F Ip; Nicole C H Lai; Yolanda Y T Li; Yuanbing Jiang; Huan Zhong; Yuewen Chen; Yulin Zhang; Shuangshuang Ma; Ronnie M N Lo; Kit Cheung; Estella P S Tong; Ho Ko; Maryam Shoai; Kin Y Mok; John Hardy; Vincent C T Mok; Timothy C Y Kwok; Amy K Y Fu; Nancy Y Ip
Journal:  Alzheimers Dement (Amst)       Date:  2020-08-05
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