Che-Kim Tan1, Hung-Jen Tang2, Chih-Cheng Lai3, Yun-Ying Chen4, Ping-Chin Chang5, Wei-Lun Liu6. 1. Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan. 2. Division of Infectious Diseases, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. 3. Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan. 4. Committee of Infection Control, Chi Mei Medical Center, Liouying, Tainan, Taiwan. 5. Division of Infectious Diseases, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan. 6. Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan. Electronic address: medrpeterliu@gmail.com.
Abstract
BACKGROUND/ PURPOSE: This study investigated the correlation between antibiotic consumption and the incidence of health care-associated infections (HCAIs) caused by imipenem-resistant Acinetobacter baumannii (IRAB) at a hospital in Taiwan from 2005 to 2010. METHODS: Data on annual consumption (defined daily dose per 1000 patient-days) of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, carbapenems, aminoglycosides, and fluoroquinolones from 2005 to 2010 were analyzed. Yearly aggregated data on the number of nonduplicate clinical IRAB isolates causing HCAI were collected. The incidence rates of HCAI caused by IRAB were defined as the number of patients infected with IRAB per 1000 inpatient-days. RESULTS: The trend of total consumption (defined daily dose per 1000 patient-days) of extended-spectrum cephalosporins, carbapenems, and fluoroquinolones was significantly increased, but the use of aminoglycosides decreased during 2005 to 2010. During the same period, the incidence of HCAI caused by IRAB gradually increased. The consumptions of carbapenems and fluoroquinolones were positively correlated with the incidence of HCAI caused by IRAB. There was no significant association between the use of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, and aminoglycosides and the incidence of HCAI caused by IRAB. CONCLUSION: The increasing use of carbapenems and fluoroquinolones was associated with the increasing incidence of HCAI caused by IRAB.
BACKGROUND/ PURPOSE: This study investigated the correlation between antibiotic consumption and the incidence of health care-associated infections (HCAIs) caused by imipenem-resistant Acinetobacter baumannii (IRAB) at a hospital in Taiwan from 2005 to 2010. METHODS: Data on annual consumption (defined daily dose per 1000 patient-days) of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, carbapenems, aminoglycosides, and fluoroquinolones from 2005 to 2010 were analyzed. Yearly aggregated data on the number of nonduplicate clinical IRAB isolates causing HCAI were collected. The incidence rates of HCAI caused by IRAB were defined as the number of patients infected with IRAB per 1000 inpatient-days. RESULTS: The trend of total consumption (defined daily dose per 1000 patient-days) of extended-spectrum cephalosporins, carbapenems, and fluoroquinolones was significantly increased, but the use of aminoglycosides decreased during 2005 to 2010. During the same period, the incidence of HCAI caused by IRAB gradually increased. The consumptions of carbapenems and fluoroquinolones were positively correlated with the incidence of HCAI caused by IRAB. There was no significant association between the use of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, and aminoglycosides and the incidence of HCAI caused by IRAB. CONCLUSION: The increasing use of carbapenems and fluoroquinolones was associated with the increasing incidence of HCAI caused by IRAB.
Authors: David de Luna; José Javier Sánchez; Miguel Peguero; Wilmary García; Sylmari Liciaga; Frank Brito; Pamela Fernández; Arlette Frías; Audrey Richard; Patricia Etienne Marie; Yori Roque; Silvia Calo Journal: Rev Panam Salud Publica Date: 2020-09-23
Authors: Noel T Mueller; Hakdong Shin; Aline Pizoni; Isabel C Werlang; Ursula Matte; Marcelo Z Goldani; Helena A S Goldani; Maria Gloria Dominguez-Bello Journal: Sci Rep Date: 2016-04-01 Impact factor: 4.379