| Literature DB >> 24685245 |
Barbera Veldhuisen1, Leendert Porcelijn2, C Ellen van der Schoot3, Masja de Haas2.
Abstract
Genotyping is an important tool in the diagnosis of disorders involving allo-immunisation to antigens present on the membranes of platelets and neutrophils. To date 28 human platelet antigens (HPAs) have been indentified on six polymorphic glycoproteins on the surface of platelets. Antibodies against HPAs play a role in foetal and neonatal alloimmune thrombocytopenia (FNAIT), post-transfusion purpura (PTP) and refractoriness to donor platelets. The 11 human neutrophil antigens (HNAs) described to date have been indentified on five polymorphic proteins on the surface of granulocytes. Antibodies to HNAs are implicated with foetal and neonatal alloimmune neutropenia (FNAIN), autoimmune neutropenia (AIN) and transfusion related acute lung injury (TRALI). In this report, we will review the molecular basis and techniques currently available for the genotyping of human platelet and neutrophil antigens.Entities:
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Year: 2014 PMID： 24685245 DOI： 10.1016/j.transci.2014.02.014
Source DB: PubMed Journal: Transfus Apher Sci ISSN： 1473-0502 Impact factor: 1.764