Literature DB >> 24683387

Beyond Thymidylate Synthase and Dihydrofolate Reductase: Impact of Non-coding microRNAs in Anticancer Chemoresistance.

Jingfang Ju1.   

Abstract

Chemoresistance is one of the major reasons for the failure of anticancer chemotherapy in treating advanced stage cancer. The mechanism of chemoresistance to fluoropyrimidines and antifolates has been extensively investigated in the past 40 years. It has been well established that thymidylate synthase (TYMS, TS) and dihydrofolate reductase (DHFR) are two major targets for fluoropyrimidines and antifolates, respectively. The regulatory mechanism of TS and DHFR expression is rather complex involving transcriptional, post-transcriptional and translational regulations. Our recent understanding of the chemoresistance mechanism has been extended beyond the simple one target/drug view. In this review, we will focus on the recent advancement of non-coding microRNAs (miRNAs) in contributing to the regulations of TS and DHFR expression, and to the chemoresistance mechanism of fluoropyrimidines and antifolates.

Entities:  

Keywords:  5-fluorouracil; Translational control; chemoresistance; dihydrofolate reductase; methotrexate; microRNA; thymidylate synthase

Year:  2012        PMID： 24683387      PMCID： PMC3966314          DOI： 10.2174/157340812800793228

Source DB:  PubMed          Journal:  Curr Enzym Inhib        ISSN： 1573-4080


  48 in total

1.  Methotrexate therapy of metastatic choriocarcinoma.

Authors:  J F HOLLAND
Journal:  Am J Obstet Gynecol       Date:  1958-01       Impact factor: 8.661

2.  The colorectal microRNAome.

Authors:  Jordan M Cummins; Yiping He; Rebecca J Leary; Ray Pagliarini; Luis A Diaz; Tobias Sjoblom; Omer Barad; Zvi Bentwich; Anna E Szafranska; Emmanuel Labourier; Christopher K Raymond; Brian S Roberts; Hartmut Juhl; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-27       Impact factor: 11.205

3.  Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer.

Authors:  Yaguang Xi; Reut Shalgi; Oystein Fodstad; Yitzhak Pilpel; Jingfang Ju
Journal:  Clin Cancer Res       Date:  2006-04-01       Impact factor: 12.531

4.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors:  A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal:  Nature       Date:  1998-02-19       Impact factor: 49.962

5.  Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Authors:  D Salonga; K D Danenberg; M Johnson; R Metzger; S Groshen; D D Tsao-Wei; H J Lenz; C G Leichman; L Leichman; R B Diasio; P V Danenberg
Journal:  Clin Cancer Res       Date:  2000-04       Impact factor: 12.531

Review 6.  Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis.

Authors:  Vera S Donnenberg; Albert D Donnenberg
Journal:  J Clin Pharmacol       Date:  2005-08       Impact factor: 3.126

7.  Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.

Authors:  Sara A Georges; Matthew C Biery; Soo-Yeon Kim; Janell M Schelter; Jane Guo; Aaron N Chang; Aimee L Jackson; Michael O Carleton; Peter S Linsley; Michele A Cleary; B Nelson Chau
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

8.  Functional structure of the promoter region of the human thymidylate synthase gene and nuclear factors that regulate the expression of the gene.

Authors:  N Horie; K Takeishi
Journal:  Nucleic Acids Symp Ser       Date:  1995

9.  Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

Authors:  N K CHAUDHURI; B J MONTAG; C HEIDELBERGER
Journal:  Cancer Res       Date:  1958-04       Impact factor: 12.701

10.  Phenotypic characterization of human colorectal cancer stem cells.

Authors:  Piero Dalerba; Scott J Dylla; In-Kyung Park; Rui Liu; Xinhao Wang; Robert W Cho; Timothy Hoey; Austin Gurney; Emina H Huang; Diane M Simeone; Andrew A Shelton; Giorgio Parmiani; Chiara Castelli; Michael F Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-04       Impact factor: 11.205
View more
  5 in total

1.  Mechanistic Biomarkers in Toxicology

Authors:  Sonia Sanajou; Gönül Şahin
Journal:  Turk J Pharm Sci       Date:  2021-06-18

2.  Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma.

Authors:  Devyani Samantarrai; Mousumi Sahu; Jyoti Roy; Bedanta Ballav Mohanty; Garima Singh; Chandra Bhushan; Bibekanand Mallick
Journal:  Sci Rep       Date:  2015-05-18       Impact factor: 4.379

3.  Implications of Circadian Rhythm Regulation by microRNAs in Colorectal Cancer.

Authors:  Song Wu; Andrew Fesler; Jingfang Ju
Journal:  Cancer Transl Med       Date:  2016-02-28

4.  The Clinical Significance of Promoter Methylation of Fluoropyrimidine Metabolizing and Cyclooxygenase Genes in Colorectal Cancer.

Authors:  Mariam Ahmed Fouad; Salem Eid Salem; Marwa M Hussien; Doaa Mohamed Badr; Abdelrahman N Zekri; Hafez Farouk Hafez; Samia A Shouman
Journal:  Epigenet Insights       Date:  2021-02-14

5.  FOXM1-induced TYMS upregulation promotes the progression of hepatocellular carcinoma.

Authors:  Liang Wang; Caiyan Shi; Jie Yu; Yilin Xu
Journal:  Cancer Cell Int       Date:  2022-01-29       Impact factor: 5.722
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.