Hanifi Kurtaran1, Nebil Ark1, K Serife Ugur1, Huseyin Sert2, Akin Altug Ozboduroglu1, Ali Kosar3, Mehmet Gunduz1. 1. Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty of Medicine, Ankara, Turkey. 2. Department of Anesthesiology, Fatih University Faculty of Medicine, Ankara, Turkey. 3. Department of Hematology, Fatih University Faculty of Medicine, Ankara, Turkey.
Abstract
BACKGROUND: Ankaferd BloodStopper (ABS) is a standardized herbal compound consisting of 5 different plant extracts. ABS, as a topical medicinal product, has been approved by the Turkish Ministry of Health for the management of dermal, external postsurgical and postdental surgery bleedings. OBJECTIVE: The aim of this study was to assess the hemostatic effect of ABS in an experimental epistaxis model. METHODS: Adult female New Zealand rabbits were used in this study. Standardized full-thickness mucosal wounds were created to provide bleeding on the right and left side of the nasal septum of rabbits with a 3-mm surgical punch. To stop bleeding, the wounds were treated with topical ABS on one side and with topical isotonic saline solution as a control on the other side of the nasal septum. Investigators were blinded to treatment. The duration of bleeding was measured in order to compare the hemo-static effect with ABS or topical isotonic saline solution. The wounds were observed for the duration of bleeding in order to compare the hemostatic effect of ABS with isotonic saline solution and acute adverse effects (AEs) for 30 minutes by a researcher blinded to treatment groups. RESULTS: Six rabbits (mean weight, 2.6 kg [range, 2.3-3.1 kg]) were used in this study. Mean (SD) bleeding time in the wounds administered ABS (98 [17] sec) was significantly less than that of the controls (266 [36] sec; P = 0.004). No AEs were observed up to 30 minutes after study initiation. CONCLUSION: This study suggests that ABS may be more effective in reducing time to hemostasis when compared with isotonic saline solution in this epistaxis model in rabbits.
BACKGROUND: Ankaferd BloodStopper (ABS) is a standardized herbal compound consisting of 5 different plant extracts. ABS, as a topical medicinal product, has been approved by the Turkish Ministry of Health for the management of dermal, external postsurgical and postdental surgery bleedings. OBJECTIVE: The aim of this study was to assess the hemostatic effect of ABS in an experimental epistaxis model. METHODS: Adult female New Zealand rabbits were used in this study. Standardized full-thickness mucosal wounds were created to provide bleeding on the right and left side of the nasal septum of rabbits with a 3-mm surgical punch. To stop bleeding, the wounds were treated with topical ABS on one side and with topical isotonicsaline solution as a control on the other side of the nasal septum. Investigators were blinded to treatment. The duration of bleeding was measured in order to compare the hemo-static effect with ABS or topical isotonicsaline solution. The wounds were observed for the duration of bleeding in order to compare the hemostatic effect of ABS with isotonicsaline solution and acute adverse effects (AEs) for 30 minutes by a researcher blinded to treatment groups. RESULTS: Six rabbits (mean weight, 2.6 kg [range, 2.3-3.1 kg]) were used in this study. Mean (SD) bleeding time in the wounds administered ABS (98 [17] sec) was significantly less than that of the controls (266 [36] sec; P = 0.004). No AEs were observed up to 30 minutes after study initiation. CONCLUSION: This study suggests that ABS may be more effective in reducing time to hemostasis when compared with isotonicsaline solution in this epistaxis model in rabbits.
Authors: Mevlut Kurt; Erkin Oztas; Sedef Kuran; Ibrahim K Onal; Murat Kekilli; Ibrahim C Haznedaroglu Journal: Am J Emerg Med Date: 2009-06 Impact factor: 2.469