Jessica Berger1, Paulomi Mehta1, Emily Bucholz1, James Dziura2, Vineet Bhandari1. 1. Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. 2. Yale Center for Analytical Sciences, Yale University School of Medicine, New Haven, Connecticut.
Abstract
OBJECTIVE: The objective of this study was to assess rates of bronchopulmonary dysplasia (BPD) and BPD/death in infants first extubated between day of life (DOL) 1 to 3 versus 4 to 7, 8+, and impact of reintubation. STUDY DESIGN: We included infants with gestational age ≤ 28 weeks, birth weight ≤ 1,000 g, and intubation on DOL 1. Proportional hazards regression modeled time to BPD and BPD/death, adjusting for potential confounders. RESULTS: Of 262 infants, 101 (38.55%), 41 (15.65%), and 120 (45.80%) were extubated between DOL 1 to 3, 4 to 7, and 8+, respectively. Extubation between DOL 4 to 7 and DOL 1 to 3 was associated with an increased hazard of developing BPD (hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.0-2.8; p < 0.05). Extubation on DOL 8+ was associated with a significantly increased hazard compared with extubation between DOL 1 to 3 (HR, 16.9; 95% CI, 10.5-27.1; p < 0.0001) and DOL 4 to 7 (HR, 10.0; 95% CI, 6.1-16.3; p < 0.0001). Similar results were noted with BPD/death. Reintubation did not affect BPD and BPD/death. CONCLUSIONS: Delaying extubation beyond the first 3 and 7 days was associated with an increased risk of BPD and BPD/death. Reintubation did not impact outcomes. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: The objective of this study was to assess rates of bronchopulmonary dysplasia (BPD) and BPD/death in infants first extubated between day of life (DOL) 1 to 3 versus 4 to 7, 8+, and impact of reintubation. STUDY DESIGN: We included infants with gestational age ≤ 28 weeks, birth weight ≤ 1,000 g, and intubation on DOL 1. Proportional hazards regression modeled time to BPD and BPD/death, adjusting for potential confounders. RESULTS: Of 262 infants, 101 (38.55%), 41 (15.65%), and 120 (45.80%) were extubated between DOL 1 to 3, 4 to 7, and 8+, respectively. Extubation between DOL 4 to 7 and DOL 1 to 3 was associated with an increased hazard of developing BPD (hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.0-2.8; p < 0.05). Extubation on DOL 8+ was associated with a significantly increased hazard compared with extubation between DOL 1 to 3 (HR, 16.9; 95% CI, 10.5-27.1; p < 0.0001) and DOL 4 to 7 (HR, 10.0; 95% CI, 6.1-16.3; p < 0.0001). Similar results were noted with BPD/death. Reintubation did not affect BPD and BPD/death. CONCLUSIONS: Delaying extubation beyond the first 3 and 7 days was associated with an increased risk of BPD and BPD/death. Reintubation did not impact outcomes. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Wissam Shalish; Lara J Kanbar; Smita Rao; Carlos A Robles-Rubio; Lajos Kovacs; Sanjay Chawla; Martin Keszler; Doina Precup; Karen Brown; Robert E Kearney; Guilherme M Sant'Anna Journal: BMC Pediatr Date: 2017-07-17 Impact factor: 2.125