Sabit Cakmak1, Robert Dales2, Lisa Marie Kauri2, Mamun Mahmud2, Keith Van Ryswyk3, Jennifer Vanos4, Ling Liu2, Premkumari Kumarathasan2, Errol Thomson2, Renaud Vincent2, Scott Weichenthal3. 1. Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada. Electronic address: sabit.cakmak@hc-sc.gc.ca. 2. Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, 50 Columbine Driveway, Ottawa, Ontario K1A 0K9, Canada. 3. Water and Air Quality Bureau, Health Canada, Ottawa, Canada. 4. Texas Tech University, Department of Geosciences, Lubbock, TX, USA.
Abstract
BACKGROUND: Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution. OBJECTIVES: We examined the relation between acute changes in cardiovascular and respiratory function, and PM2.5-associated-metals. METHODS: Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals were compared to daily changes in physiologic measures in 59 healthy subjects who spent 5-days near a steel plant and 5-days on a college campus. RESULTS: Interquartile increases in calcium, cadmium, lead, strontium, tin, vanadium and zinc were associated with statistically significant increases in heart rate of 1-3 beats per minute, increases of 1-3 mmHg in blood pressure and/or lung function decreases of up to 4% for total lung capacity. CONCLUSION: Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology. Crown
BACKGROUND: Studying the physiologic effects of components of fine particulate mass (PM2.5) could contribute to a better understanding of the nature of toxicity of air pollution. OBJECTIVES: We examined the relation between acute changes in cardiovascular and respiratory function, and PM2.5-associated-metals. METHODS: Using generalized linear mixed models, daily changes in ambient PM2.5-associated metals were compared to daily changes in physiologic measures in 59 healthy subjects who spent 5-days near a steel plant and 5-days on a college campus. RESULTS: Interquartile increases in calcium, cadmium, lead, strontium, tin, vanadium and zinc were associated with statistically significant increases in heart rate of 1-3 beats per minute, increases of 1-3 mmHg in blood pressure and/or lung function decreases of up to 4% for total lung capacity. CONCLUSION: Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology. Crown
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