Literature DB >> 24681883

Prion protein and cancers.

Xiaowen Yang1, Yan Zhang2, Lihua Zhang3, Tianlin He4, Jie Zhang5, Chaoyang Li6.   

Abstract

The normal cellular prion protein, PrP(C) is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrP(C) remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrP(C). In this paper, we reviewed the potential roles that PrP(C) plays in cell physiology and focused on its contribution to tumorigenesis.
© The Author 2014. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Entities:  

Keywords:  prion disease; prion protein; tumorigenesis

Mesh：

Substances：

Year:  2014        PMID： 24681883     DOI： 10.1093/abbs/gmu019

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  10 in total

1.  A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells.

Authors:  Liheng Yang; Yan Zhang; Lipeng Hu; Ying Zhu; Man-Sun Sy; Chaoyang Li
Journal:  Virol Sin       Date:  2014-08-14       Impact factor: 4.327

2.  Prion Protein Expression is Correlated with Glioma Grades.

Authors:  Qiaoli Luo; Yisong Wang; Dongying Fan; Shijie Wang; Peigang Wang; Jing An
Journal:  Virol Sin       Date:  2020-03-31       Impact factor: 4.327

3.  Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility.

Authors:  Liheng Yang; Zhenxing Gao; Lipeng Hu; Guiru Wu; Xiaowen Yang; Lihua Zhang; Ying Zhu; Boon-Seng Wong; Wei Xin; Man-Sun Sy; Chaoyang Li
Journal:  J Biol Chem       Date:  2015-12-18       Impact factor: 5.157

Review 4.  Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer's Disease.

Authors:  Chang Kong; Hao Xie; Zhenxing Gao; Ming Shao; Huan Li; Run Shi; Lili Cai; Shanshan Gao; Taolei Sun; Chaoyang Li
Journal:  Virol Sin       Date:  2019-05-15       Impact factor: 4.327

5.  Cellular prion protein contributes to LS 174T colon cancer cell carcinogenesis by increasing invasiveness and resistance against doxorubicin-induced apoptosis.

Authors:  Cornelius Kwang-Lee Chieng; Yee-How Say
Journal:  Tumour Biol       Date:  2015-05-17

6.  Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication.

Authors:  Huixia Zhang; Shanshan Gao; Rongjuan Pei; Xinwen Chen; Chaoyang Li
Journal:  Virol Sin       Date:  2017-10-25       Impact factor: 4.327

7.  Cellular Prion Protein (PrPc) and Hypoxia: True to Each Other in Good Times and in Bad, in Sickness, and in Health.

Authors:  Sanja Ramljak; Holger Herlyn; Inga Zerr
Journal:  Front Cell Neurosci       Date:  2016-12-19       Impact factor: 5.505

8.  Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway.

Authors:  Jun Hee Lee; Chul Won Yun; Sang Hun Lee
Journal:  Biomol Ther (Seoul)       Date:  2018-05-01       Impact factor: 4.634

9.  Cellular Prion Protein Is Closely Associated with Early Recurrence and Poor Survival in Patients with Hepatocellular Carcinoma.

Authors:  Mo-Jong Kim; Yoon-Ah Cho; Eunhye Kim; Ji-Young Choe; Ji-Won Park; Junyong Lee; Jung-Woo Lee; Sung-Hoon Moon; Yong-Sun Kim; Sung-Eun Kim; Eun-Kyoung Choi
Journal:  Diagnostics (Basel)       Date:  2022-07-05

10.  The Role of Prion Protein Expression in Predicting Gastric Cancer Prognosis.

Authors:  Zhaoqing Tang; Ji Ma; Wei Zhang; Changguo Gong; Jing He; Ying Wang; Guohua Yu; Chonggang Yuan; Xuefei Wang; Yihong Sun; Jiyan Ma; Fenglin Liu; Yulan Zhao
Journal:  J Cancer       Date:  2016-05-20       Impact factor: 4.207
  10 in total

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