Guilherme Nogueira de Oliveira1, João Marcelo K Lessa2, Ana Paula Gonçalves1, Eduardo Jardel Portela1, Josemir W Sander3, Antonio Lucio Teixeira4. 1. Neuropsychiatric Unit, Neurology Division, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Epilepsy Treatment Advanced Centre (NATE), Felicio Rocho Hospital, Belo Horizonte, Brazil. 2. Neuropsychiatric Unit, Neurology Division, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 3. NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical & Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London WC1N 3BG, and Epilepsy Society, Chalfont St Peter, SL9 0RJ, UK; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede 2103SW, The Netherlands; SEIN - Epilepsy Institutes in the Netherlands Foundation, Heemstede, The Netherlands. 4. Neuropsychiatric Unit, Neurology Division, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: altexr@gmail.com.
Abstract
PURPOSE: We aimed to assess and compare the psychometric properties of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), Hospital Anxiety and Depression Scale Depression Subscale (HADS-D), and Beck Depression Inventory (BDI) as screening instruments for depression and suicidality in people with epilepsy. METHODS: One hundred twenty-six people (54% women) diagnosed with epilepsy were recruited and evaluated on their sociodemographic and clinical features. Depression and suicide risk were assessed with a structured psychiatric interview, the Mini International Neuropsychiatric Interview (MINI-Plus), and the performance of NDDI-E, HADS-D, and BDI was evaluated. RESULTS: The sensitivity and specificity of BDI for the diagnosis of depression was around 90%; HADS-D and NDDI-E have sensitivity higher than 80%, and specificity was greater than 75%. For identifying suicide risk, the NDDI-E sensitivity was 92.9%, and HADS-D sensitivity was 85.7%, and a reasonable specificity (68%) was observed for both instruments. All instruments showed a negative predictive value of over 90%. Comparisons of the areas under the ROC curve for these instruments were not significantly different regarding depression or moderate/severe risk of suicide. CONCLUSION: All three instruments evaluated have clinical utility in the screening of depression in people with epilepsy. Both NDDI-E and HADS-D are brief efficient screening instruments to identify depression in people with epilepsy. The BDI is a more robust instrument, but it takes longer to apply, which hampers its use by busy clinicians and by people with cognitive impairment.
PURPOSE: We aimed to assess and compare the psychometric properties of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), Hospital Anxiety and Depression Scale Depression Subscale (HADS-D), and Beck Depression Inventory (BDI) as screening instruments for depression and suicidality in people with epilepsy. METHODS: One hundred twenty-six people (54% women) diagnosed with epilepsy were recruited and evaluated on their sociodemographic and clinical features. Depression and suicide risk were assessed with a structured psychiatric interview, the Mini International Neuropsychiatric Interview (MINI-Plus), and the performance of NDDI-E, HADS-D, and BDI was evaluated. RESULTS: The sensitivity and specificity of BDI for the diagnosis of depression was around 90%; HADS-D and NDDI-E have sensitivity higher than 80%, and specificity was greater than 75%. For identifying suicide risk, the NDDI-E sensitivity was 92.9%, and HADS-D sensitivity was 85.7%, and a reasonable specificity (68%) was observed for both instruments. All instruments showed a negative predictive value of over 90%. Comparisons of the areas under the ROC curve for these instruments were not significantly different regarding depression or moderate/severe risk of suicide. CONCLUSION: All three instruments evaluated have clinical utility in the screening of depression in people with epilepsy. Both NDDI-E and HADS-D are brief efficient screening instruments to identify depression in people with epilepsy. The BDI is a more robust instrument, but it takes longer to apply, which hampers its use by busy clinicians and by people with cognitive impairment.
Authors: Charissa Millevert; Stijn Van Hees; Joseph Nelson Siewe Fodjo; Veerle Wijtvliet; Edlaine Faria de Moura Villela; Barbara Rosso; Antonio Gil-Nagel; Sarah Weckhuysen; Robert Colebunders Journal: Epilepsy Behav Date: 2021-01-29 Impact factor: 3.337
Authors: Laurent M Willems; Nina Watermann; Saskia Richter; Lara Kay; Anke M Hermsen; Susanne Knake; Felix Rosenow; Adam Strzelczyk Journal: Front Neurol Date: 2018-06-15 Impact factor: 4.003