Literature DB >> 24681203

ORC1/CDC6 and MCM7 distinct associate with chromatin through Trypanosoma cruzi life cycle.

Simone Calderano1, Patricia Godoy2, Daiane Soares1, Osvaldo Augusto Sant'Anna3, Sergio Schenkman4, M Carolina Elias5.   

Abstract

Trypanosoma cruzi alternates between replicative and non-replicative stages. We analyzed the expression of components of the pre-replication machinery TcORC1/CDC6 and TcMCM7 and their interaction with DNA in all T. cruzi stages. TcORC1/CDC6 remains in the nuclear space during all stages of the life cycle and interacts with DNA in the replicative stages; however, it does not bind to DNA in the non-replicative forms. Moreover, TcMCM7 is not present in the non-replicative stages. These data suggest that the lacking of DNA replication during the T. cruzi life cycle may be a consequence of the blocking of TcORC1/CDC6-DNA interaction and of the down regulation of the TcMCM7 expression.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  DNA replication; MCM7; ORC1/CDC6; Trypanosoma cruzi

Mesh：

Substances：

Year:  2014        PMID： 24681203     DOI： 10.1016/j.molbiopara.2014.03.004

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  7 in total

1.  Quantitative Proteomic Analysis of Replicative and Nonreplicative Forms Reveals Important Insights into Chromatin Biology of Trypanosoma cruzi.

Authors:  Teresa Cristina Leandro de Jesus; Simone Guedes Calderano; Francisca Nathalia de Luna Vitorino; Ricardo Pariona Llanos; Mariana de Camargo Lopes; Christiane Bezerra de Araújo; Otavio Henrique Thiemann; Marcelo da Silva Reis; Maria Carolina Elias; Julia Pinheiro Chagas da Cunha
Journal:  Mol Cell Proteomics       Date:  2016-11-16       Impact factor: 5.911

2.  HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani.

Authors:  Devanand Kumar; Swati Saha
Journal:  Nucleic Acids Res       Date:  2015-05-06       Impact factor: 16.971

3.  Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi.

Authors:  Raphael Souza Pavani; Marcelo Santos da Silva; Carlos Alexandre Henrique Fernandes; Flavia Souza Morini; Christiane Bezerra Araujo; Marcos Roberto de Mattos Fontes; Osvaldo Augusto Sant'Anna; Carlos Renato Machado; Maria Isabel Cano; Stenio Perdigão Fragoso; Maria Carolina Elias
Journal:  PLoS Negl Trop Dis       Date:  2016-12-16

4.  Transcriptome-wide analysis of the Trypanosoma cruzi proliferative cycle identifies the periodically expressed mRNAs and their multiple levels of control.

Authors:  Santiago Chávez; Guillermo Eastman; Pablo Smircich; Lorena Lourdes Becco; Carolina Oliveira-Rizzo; Rafael Fort; Mariana Potenza; Beatriz Garat; José Roberto Sotelo-Silveira; María Ana Duhagon
Journal:  PLoS One       Date:  2017-11-28       Impact factor: 3.240

Review 5.  Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems.

Authors:  Marcelo S da Silva; Raphael S Pavani; Jeziel D Damasceno; Catarina A Marques; Richard McCulloch; Luiz Ricardo Orsini Tosi; Maria Carolina Elias
Journal:  Trends Parasitol       Date:  2017-08-24

6.  Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi.

Authors:  Loyze P de Lima; Simone G Calderano; Marcelo S da Silva; Christiane B de Araujo; Elton J R Vasconcelos; Leo K Iwai; Claudio A Pereira; Stenio P Fragoso; M Carolina Elias
Journal:  Sci Rep       Date:  2019-02-27       Impact factor: 4.379

7.  Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation.

Authors:  Catarina A Marques; Calvin Tiengwe; Leandro Lemgruber; Jeziel D Damasceno; Alan Scott; Daniel Paape; Lucio Marcello; Richard McCulloch
Journal:  Nucleic Acids Res       Date:  2016-03-06       Impact factor: 16.971
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.