| Literature DB >> 24681048 |
Maria Letizia Manca1, Ines Castangia1, Pietro Matricardi2, Sandrina Lampis3, Xavier Fernàndez-Busquets4, Anna Maria Fadda1, Maria Manconi1.
Abstract
A self-assembled hybrid phospholipid vesicular system containing various penetration enhancers - ethanol, Transcutol and propylenglycol - was prepared and characterized. The effects of the different alcohol or polyalcohols structure and their concentration on the features of the assembled vesicles were evaluated using a combination of different techniques, including cryo-transmission electron microscopy, laser light scattering, differential scanning calorimetry, small- and wide-angle X-ray scattering and rheological analysis. These techniques allow explaining the structural rearrangements of the bilayer assembly due to the alcohol or polyalcohol addition. X-ray scattering studies showed that such addition at the highest concentration (20%) allowed structure modification to oligolamellar vesicles and a bilayer transition to interdigitated phase. Rheological studies confirmed the importance of alcohol or polyalcohol in the structuring dispersions probably due to a partial tilting of phosphatidylcholine acyl chains forming interdigitated and interconnected bilayer vesicles.Entities:
Keywords: (Poly)alcohols; Cryo-TEM; DSC; Liposomes; Penetration Enhancer containing Vesicle (PEVs); Rheology; SAXS
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Year: 2014 PMID： 24681048 DOI： 10.1016/j.colsurfb.2014.03.010
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268