Jacqueline Limberg1, Barbara Morgan2, William Schrage3. 1. Department of Kinesiology, School of Education, University of Wisconsin - Madison, Madison, WI 53706, United States. Electronic address: limberg.jacqueline@mayo.edu. 2. Department of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI 53706, United States. 3. Department of Kinesiology, School of Education, University of Wisconsin - Madison, Madison, WI 53706, United States.
Abstract
AIM: Based on reports of exaggerated blood pressure responses to whole-body exercise in patients with metabolic syndrome (MetSyn), we tested the hypothesis that MetSyn adults would exhibit augmented sympathetic and pressor responses to mechanoreflex and metaboreflex activation when compared with healthy, age-matched control subjects. METHODS: We studied 12 adults with MetSyn (34±3years) and 12 healthy control subjects (34±3years). Heart rate (HR; ECG), blood pressure (BP; finger photoplethysmography), and MSNA (microneurography of the peroneal nerve) were measured during: (1) static handgrip exercise at 15% of maximal voluntary contraction (MVC), and (2) static handgrip exercise at 30% MVC to fatigue, followed by post-exercise ischemia (PEI). Increases in MSNA, HR, and BP were assessed. RESULTS: During static exercise at both 15 and 30% MVC, increases in MSNA, HR, and BP were not different between groups. MSNA remained significantly elevated from baseline during PEI and responses were not different between groups. CONCLUSION: Sympathetic and pressor responses to mechanoreflex and metaboreflex activation are not augmented in younger adults with MetSyn.
AIM: Based on reports of exaggerated blood pressure responses to whole-body exercise in patients with metabolic syndrome (MetSyn), we tested the hypothesis that MetSyn adults would exhibit augmented sympathetic and pressor responses to mechanoreflex and metaboreflex activation when compared with healthy, age-matched control subjects. METHODS: We studied 12 adults with MetSyn (34±3years) and 12 healthy control subjects (34±3years). Heart rate (HR; ECG), blood pressure (BP; finger photoplethysmography), and MSNA (microneurography of the peroneal nerve) were measured during: (1) static handgrip exercise at 15% of maximal voluntary contraction (MVC), and (2) static handgrip exercise at 30% MVC to fatigue, followed by post-exercise ischemia (PEI). Increases in MSNA, HR, and BP were assessed. RESULTS: During static exercise at both 15 and 30% MVC, increases in MSNA, HR, and BP were not different between groups. MSNA remained significantly elevated from baseline during PEI and responses were not different between groups. CONCLUSION: Sympathetic and pressor responses to mechanoreflex and metaboreflex activation are not augmented in younger adults with MetSyn.
Authors: Sara S Jarvis; Tiffany B VanGundy; M Melyn Galbreath; Shigeki Shibata; Kazunobu Okazaki; Miriam F Reelick; Benjamin D Levine; Qi Fu Journal: Am J Physiol Regul Integr Comp Physiol Date: 2011-04-20 Impact factor: 3.619
Authors: Gabrielle A Dillon; Zachary S Lichter; Lacy M Alexander; Lauro C Vianna; Jing Wang; Paul J Fadel; Jody L Greaney Journal: J Appl Physiol (1985) Date: 2020-09-17
Authors: Seth W Holwerda; Robert M Restaino; Camila Manrique; Guido Lastra; James P Fisher; Paul J Fadel Journal: Am J Physiol Heart Circ Physiol Date: 2015-11-13 Impact factor: 4.733
Authors: André Rodrigues Lourenço Dias; Katrice Almeida de Souza; Laila Cândida de Jesus Lima de Sousa; Kamila Meireles Dos Santos; Gabriel Kolesny Tricot; Jaqueline Alves de Araújo; Lucieli Teresa Cambri; Gisela Arsa Journal: J Clin Transl Res Date: 2017-09-23