Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Functional selectivity of GPCR signaling in animals.

Literature DB >> 24680435

Functional selectivity of GPCR signaling in animals.

Abstract

At one time, G protein-coupled receptors were envisioned to simply relay either inhibitory or stimulatory binary signals through engaging particular G proteins. These receptors are now viewed as complex, multidimensional triggers of a variety of potential signaling cascades. This review will showcase current attempts to elucidate biased signaling and functional selectivity in tissues and organs as well as in the whole animal. In addition, it will emphasize the challenges that are inherent in attributing bias in a living system as well as offer opinions as to the manner in which these problems may be approached.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2013 PMID： 24680435 PMCID： PMC4349326 DOI： 10.1016/j.ceb.2013.11.010

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

55 in total

1. Enhanced morphine analgesia in mice lacking beta-arrestin 2.

Authors: L M Bohn; R J Lefkowitz; R R Gainetdinov; K Peppel; M G Caron; F T Lin
Journal: Science Date: 1999-12-24 Impact factor: 47.728

2. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

Authors: L M Bohn; R R Gainetdinov; F T Lin; R J Lefkowitz; M G Caron
Journal: Nature Date: 2000-12-07 Impact factor: 49.962

Review 3. Biased agonism at the parathyroid hormone receptor: a demonstration of functional selectivity in bone metabolism.

Authors: B N Bohinc; D Gesty-Palmer
Journal: Mini Rev Med Chem Date: 2012-08 Impact factor: 3.862

4. Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

Authors: Claire Gaveriaux-Ruff; Chihiro Nozaki; Xavier Nadal; Xavier C Hever; Raphael Weibel; Audrey Matifas; David Reiss; Dominique Filliol; Mohammed A Nassar; John N Wood; Rafael Maldonado; Brigitte L Kieffer
Journal: Pain Date: 2011-02-03 Impact factor: 6.961

Review 5. Nanobody stabilization of G protein-coupled receptor conformational states.

Authors: Jan Steyaert; Brian K Kobilka
Journal: Curr Opin Struct Biol Date: 2011-07-21 Impact factor: 6.809

6. Morphine side effects in beta-arrestin 2 knockout mice.

Authors: Kirsten M Raehal; Julia K L Walker; Laura M Bohn
Journal: J Pharmacol Exp Ther Date: 2005-05-25 Impact factor: 4.030

7. β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.

Authors: Diane Gesty-Palmer; Ling Yuan; Bronwen Martin; William H Wood; Mi-Hye Lee; Michael G Janech; Lam C Tsoi; W Jim Zheng; Louis M Luttrell; Stuart Maudsley
Journal: Mol Endocrinol Date: 2013-01-11

Review 8. Therapeutic potential of β-arrestin- and G protein-biased agonists.

Authors: Erin J Whalen; Sudarshan Rajagopal; Robert J Lefkowitz
Journal: Trends Mol Med Date: 2010-12-21 Impact factor: 11.951

Review 9. The mechanism and mitigation of niacin-induced flushing.

Authors: V S Kamanna; S H Ganji; M L Kashyap
Journal: Int J Clin Pract Date: 2009-09 Impact factor: 2.503

10. In vivo delta opioid receptor internalization controls behavioral effects of agonists.

Authors: Amynah A A Pradhan; Jérôme A J Becker; Grégory Scherrer; Petra Tryoen-Toth; Dominique Filliol; Audrey Matifas; Dominique Massotte; Claire Gavériaux-Ruff; Brigitte L Kieffer
Journal: PLoS One Date: 2009-05-01 Impact factor: 3.240

26 in total

1. Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.

Authors: Céline M'Kadmi; Jean-Philippe Leyris; Lauriane Onfroy; Céline Galés; Aude Saulière; Didier Gagne; Marjorie Damian; Sophie Mary; Mathieu Maingot; Séverine Denoyelle; Pascal Verdié; Jean-Alain Fehrentz; Jean Martinez; Jean-Louis Banères; Jacky Marie
Journal: J Biol Chem Date: 2015-09-11 Impact factor: 5.157

2. A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

Authors: Jianxin Hu; Matthew Stern; Luis E Gimenez; Lizzy Wanka; Lu Zhu; Mario Rossi; Jaroslawna Meister; Asuka Inoue; Annette G Beck-Sickinger; Vsevolod V Gurevich; Jürgen Wess
Journal: J Biol Chem Date: 2016-02-05 Impact factor: 5.157

10. Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding.

Authors: Jian-Xin Cheng; Tao Cheng; Wei-Hua Li; Gui-Xia Liu; Wei-Liang Zhu; Yun Tang
Journal: Acta Pharmacol Sin Date: 2017-10-19 Impact factor: 6.150

Functional selectivity of GPCR signaling in animals.

1. Enhanced morphine analgesia in mice lacking beta-arrestin 2.

2. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

Review 3. Biased agonism at the parathyroid hormone receptor: a demonstration of functional selectivity in bone metabolism.

4. Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

Review 5. Nanobody stabilization of G protein-coupled receptor conformational states.

6. Morphine side effects in beta-arrestin 2 knockout mice.

7. β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.

Review 8. Therapeutic potential of β-arrestin- and G protein-biased agonists.

Review 9. The mechanism and mitigation of niacin-induced flushing.

10. In vivo delta opioid receptor internalization controls behavioral effects of agonists.

1. Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.

2. A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

3. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.

4. Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor.

Review 5. Allosteric communication pipelines in G-protein-coupled receptors.

6. Approaches to Assess Biased Signaling at the CB1R Receptor.

7. Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors.

Review 8. Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets.

9. The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism.

10. Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding.