Derek M Miller1, Cliff S Klein2, Nina L Suresh2, William Z Rymer3. 1. Northwestern University Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL 60611, USA; Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL 60611, USA. Electronic address: derek@u.northwestern.edu. 2. Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL 60611, USA. 3. Northwestern University Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL 60611, USA; Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL 60611, USA.
Abstract
OBJECTIVE: Indirect evidence suggests that lateralized changes in motoneuron behavior post-stroke are potentially due to a depolarizing supraspinal drive to the motoneuron pool, but the pathways responsible are unknown. In this study, we assessed vestibular evoked myogenic potentials (VEMPs) in the neck muscles of hemispheric stroke survivors with contralesional spasticity to quantify the relative levels of vestibular drive to the spastic-paretic and contralateral motoneuron pools. METHODS: VEMPs were recorded from each sternocleidomastoid muscle in chronic stroke survivors. Side-to-side differences in cVEMP amplitude were calculated and expressed as an asymmetry ratio, a proxy for the relative amount of vestibular drive to each side. RESULTS: Spastic-paretic VEMPs were larger than contralateral VEMPs in 13/16 subjects. There was a strong positive relationship between the degree of asymmetry and the severity of spasticity in this subset of subjects. Remaining subjects had larger contralateral responses. CONCLUSION: Vestibular drive to cervical motoneurons is asymmetric in spastic stroke survivors, supporting our hypothesis that there is an imbalance in descending vestibular drive to motoneuron pools post-stroke. We speculate this imbalance is a consequence of the unilateral disruption of inhibitory corticobulbar projections to the vestibular nuclei. SIGNIFICANCE: This study sheds new light on the underlying mechanisms of post-stroke spasticity.
OBJECTIVE: Indirect evidence suggests that lateralized changes in motoneuron behavior post-stroke are potentially due to a depolarizing supraspinal drive to the motoneuron pool, but the pathways responsible are unknown. In this study, we assessed vestibular evoked myogenic potentials (VEMPs) in the neck muscles of hemispheric stroke survivors with contralesional spasticity to quantify the relative levels of vestibular drive to the spastic-paretic and contralateral motoneuron pools. METHODS: VEMPs were recorded from each sternocleidomastoid muscle in chronic stroke survivors. Side-to-side differences in cVEMP amplitude were calculated and expressed as an asymmetry ratio, a proxy for the relative amount of vestibular drive to each side. RESULTS:Spastic-paretic VEMPs were larger than contralateral VEMPs in 13/16 subjects. There was a strong positive relationship between the degree of asymmetry and the severity of spasticity in this subset of subjects. Remaining subjects had larger contralateral responses. CONCLUSION: Vestibular drive to cervical motoneurons is asymmetric in spastic stroke survivors, supporting our hypothesis that there is an imbalance in descending vestibular drive to motoneuron pools post-stroke. We speculate this imbalance is a consequence of the unilateral disruption of inhibitory corticobulbar projections to the vestibular nuclei. SIGNIFICANCE: This study sheds new light on the underlying mechanisms of post-stroke spasticity.
Authors: Disa K Sommerfeld; Elsy U-B Eek; Anna-Karin Svensson; Lotta Widén Holmqvist; Magnus H von Arbin Journal: Stroke Date: 2003-12-18 Impact factor: 7.914