| Literature DB >> 24679441 |
Bui Thi Thuy Luyen1, Bui Huu Tai2, Nguyen Phuong Thao2, Kim Ji Eun1, Ji Yun Cha3, Ming Jie Xin3, Young Mi Lee4, Young Ho Kim5.
Abstract
Two new compounds, euphorbinoside (1) and dehydropicrorhiza acid methyl diester (2), along with 24 known compounds (3-26) were isolated from Euphorbia humifusa Willd. The effects of these compounds on soluble epoxide hydrolase (sEH) inhibitory activity were evaluated. Flavonoid compounds (10-21) exhibited high sEH inhibitory activity. Among them, compounds 12, 13, and 19 greatly inhibited sEH enzymatic activity, with IC50 values as low as 18.05±1.17, 18.64±1.83, and 17.23±0.84 μM, respectively. In addition, the effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor alpha (TNF-α) production by RAW 264.7 cells were investigated. Compounds 3-6, 8, 18, 20-23, and 25-26 inhibited the production of both NO and TNF-α, with IC50 values ranging from 11.1±0.9 to 45.3±1.6 μM and 14.4±0.5 to 44.5±1.2 μM, respectively.Entities:
Keywords: Dehydropicrorhiza acid methyl diester; Euphorbia humifusa; Euphorbinoside; NO; Soluble epoxide hydrolase; TNF-α
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Year: 2014 PMID： 24679441 DOI： 10.1016/j.bmcl.2014.03.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823