Literature DB >> 2467877

Antigenic structure of the hexacosapeptide melittin: evidence for three determinants, one with a helical conformation.

R von Grünigen1, C H Schneider.   

Abstract

ELISA-based epitope analysis was performed using rabbit polyclonal antisera against melittin. Antigenic sites were found at the C-terminus, in the middle section and within the N-terminal helix. Antibodies against the helical segment could discriminate between two faces of the amphiphilic helix. The antigenic sites include the bulk of the melittin hexacosapeptide, which is synonymous with a very high epitope density.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2467877      PMCID： PMC1385217     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  9 in total

1.  A quantitative immunochemical measure of the primary interaction between I BSA and antibody.

Authors:  R S FARR
Journal:  J Infect Dis       Date:  1958 Nov-Dec       Impact factor: 5.226

2.  [A new method for synthesis of peptides: activation of the carboxyl group with dicyclohexylcarbodiimide using 1-hydroxybenzotriazoles as additives].

Authors:  W König; R Geiger
Journal:  Chem Ber       Date:  1970

Review 3.  The antigenic structure of proteins: a reappraisal.

Authors:  D C Benjamin; J A Berzofsky; I J East; F R Gurd; C Hannum; S J Leach; E Margoliash; J G Michael; A Miller; E M Prager
Journal:  Annu Rev Immunol       Date:  1984       Impact factor: 28.527

4.  High-resolution 1H-NMR studies of monomeric melittin in aqueous solution.

Authors:  J Lauterwein; L R Brown; K Wüthrich
Journal:  Biochim Biophys Acta       Date:  1980-04-25

5.  High-resolution 1H-NMR studies of self-aggregation of melittin in aqueous solution.

Authors:  L R Brown; J Lauterwein; K Wüthrich
Journal:  Biochim Biophys Acta       Date:  1980-04-25

6.  Chain-length dependence for secondary structure formation of homo-oligopeptides from epsilon-tert.-butyloxycarbonyl-L-lysine with a lipophilic C-terminal group.

Authors:  C Toniolo; G M Bonora; I F Lüscher; C H Schneider
Journal:  Int J Pept Protein Res       Date:  1984-01

7.  Equilibrium in the protein-immobilized-ligand-soluble-ligand system: estimation of dissociation constants of protein-soluble-ligand complexes from binding-inhibition data.

Authors:  V Horejsí; V Matousek
Journal:  Mol Immunol       Date:  1985-02       Impact factor: 4.407

8.  The structure of melittin in lipid bilayer membranes.

Authors:  A F Drake; R C Hider
Journal:  Biochim Biophys Acta       Date:  1979-08-07

9.  Diagnostic reagents in drug allergy: immunochemical specificity in the 1,2-diphenyl-pyrazolidinedione series.

Authors:  M F Kasper; C H Schneider; H Rolli; B D Angst; A L de Weck
Journal:  Immunobiology       Date:  1986-10       Impact factor: 3.144
  9 in total
  2 in total

1.  Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.

Authors:  C A Akdis; M Akdis; T Blesken; D Wymann; S S Alkan; U Müller; K Blaser
Journal:  J Clin Invest       Date:  1996-10-01       Impact factor: 14.808

2.  Role of interleukin 10 in specific immunotherapy.

Authors:  C A Akdis; T Blesken; M Akdis; B Wüthrich; K Blaser
Journal:  J Clin Invest       Date:  1998-07-01       Impact factor: 14.808
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.