Richard A Owings1, Charles M Quick. 1. From the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Abstract
CONTEXT: Developed in conjunction with molecular and progression data, the sequence classification schema for endometrial intraepithelial neoplasia (EIN)/benign hyperplasia (BH) provides an easy to adopt and reproducible method for classification of endometrial biopsies. OBJECTIVE: To review current data supporting the use of BH/EIN to classify endometrial biopsies, and to discuss the hormone-driven endometrial sequence from anovulation/disordered proliferative endometrium through BH and EIN and their diagnostic difficulty. DATA SOURCES: A comprehensive review of EIN literature based on literature indexed by PubMed (National Library of Medicine) and Google Scholar. CONCLUSIONS: The BH/EIN schema is gaining wider acceptance among pathologist and clinicians. The research leading to the EIN criteria is based on molecular and progression data. The BH/EIN schema has better reproducibility among pathologists, is intuitively easy to use, and requires understanding of endometrial physiology and neoplasia.
CONTEXT: Developed in conjunction with molecular and progression data, the sequence classification schema for endometrial intraepithelial neoplasia (EIN)/benign hyperplasia (BH) provides an easy to adopt and reproducible method for classification of endometrial biopsies. OBJECTIVE: To review current data supporting the use of BH/EIN to classify endometrial biopsies, and to discuss the hormone-driven endometrial sequence from anovulation/disordered proliferative endometrium through BH and EIN and their diagnostic difficulty. DATA SOURCES: A comprehensive review of EIN literature based on literature indexed by PubMed (National Library of Medicine) and Google Scholar. CONCLUSIONS: The BH/EIN schema is gaining wider acceptance among pathologist and clinicians. The research leading to the EIN criteria is based on molecular and progression data. The BH/EIN schema has better reproducibility among pathologists, is intuitively easy to use, and requires understanding of endometrial physiology and neoplasia.
Authors: Peter A Sanderson; Hilary O D Critchley; Alistair R W Williams; Mark J Arends; Philippa T K Saunders Journal: Hum Reprod Update Date: 2017-03-01 Impact factor: 15.610