Literature DB >> 2467823

Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists.

H Meurs1, A F Roffel, J B Postema, A Timmermans, C R Elzinga, H F Kauffman, J Zaagsma.   

Abstract

The relationship between bovine tracheal muscle contraction and phosphoinositide metabolism was studied with the muscarinic agonists, methacholine, oxotremorine, and McN-A-343. Analysis of the dose-response curves for contraction and inositol phosphates accumulation with these agonists demonstrated a direct relationship between the two parameters, with a considerable reserve of inositol phosphate production for the full contractile agonists, methacholine and oxotremorine, and no reserve for the partial agonist, McN-A-343.

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Year:  1988        PMID： 2467823     DOI： 10.1016/0014-2999(88)90331-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  21 in total

1.  Functional characterization of serum- and growth factor-induced phenotypic changes in intact bovine tracheal smooth muscle.

Authors:  Reinoud Gosens; Herman Meurs; Mechteld M Grootte Bromhaar; Sue McKay; S Adriaan Nelemans; Johan Zaagsma
Journal:  Br J Pharmacol       Date:  2002-10       Impact factor: 8.739

2.  Differential Rho-kinase dependency of full and partial muscarinic receptor agonists in airway smooth muscle contraction.

Authors:  Dedmer Schaafsma; Mark Boterman; Anne-Margreet de Jong; Iris Hovens; Jelte-Maarten Penninks; S Adriaan Nelemans; Herman Meurs; Johan Zaagsma
Journal:  Br J Pharmacol       Date:  2006-04       Impact factor: 8.739

3.  Endothelin-1-induced [3H]-inositol phosphate accumulation in rat trachea.

Authors:  P J Henry; P J Rigby; G J Self; J M Preuss; R G Goldie
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

4.  Proceedings of the British Pharmacological Society Meeting. Sheffield, 18-20th April 1990.

Authors: 
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

5.  Beta-agonist-induced constitutive beta(2)-adrenergic receptor activity in bovine tracheal smooth muscle.

Authors:  B de Vries; H Meurs; A F Roffel; C R Elzinga; B H Hoiting; M M de Vries; J Zaagsma
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

6.  Intracellular calcium in canine cultured tracheal smooth muscle cells is regulated by M3 muscarinic receptors.

Authors:  C M Yang; Y L Yo; Y Y Wang
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

7.  Mucosa-dependent muscarinic liberation of prostaglandins from rat isolated trachea.

Authors:  G Brunn; I Wessler; K Racké
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

8.  Formoterol, fenoterol, and salbutamol as partial agonists for relaxation of maximally contracted guinea pig tracheae: comparison of relaxation with receptor binding.

Authors:  H Lemoine; C Overlack; A Köhl; H Worth; D Reinhardt
Journal:  Lung       Date:  1992       Impact factor: 2.584

9.  Modulation of agonist-induced phosphoinositide metabolism, Ca2+ signalling and contraction of airway smooth muscle by cyclic AMP-dependent mechanisms.

Authors:  B H Hoiting; H Meurs; M Schuiling; R Kuipers; C R Elzinga; J Zaagsma
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

10.  Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle.

Authors:  R A Challiss; N Patel; J R Arch
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739
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