K E Corey1, T L Stanley, J Misdraji, C Scirica, J Pratt, A Hoppin, M Misra. 1. Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Weight Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
BACKGROUND/ OBJECTIVE: We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS). RESULTS: On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with NASH than those without NASH. Following WLS, 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss. CONCLUSION: We found that NASH is underdiagnosed in adolescents referred for WLS, and that hyperinsulinaemia, HOMA-IR and HbA1c can aid in identifying high-risk patients.
BACKGROUND/ OBJECTIVE: We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS). RESULTS: On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in patients with NASH than those without NASH. Following WLS, 40% of patients with NASH had persistently elevated aminotransferase levels despite weight loss. CONCLUSION: We found that NASH is underdiagnosed in adolescents referred for WLS, and that hyperinsulinaemia, HOMA-IR and HbA1c can aid in identifying high-risk patients.
Authors: Ayako Suzuki; Manal F Abdelmalek; Jeffrey B Schwimmer; Joel E Lavine; Ann O Scheimann; Aynur Unalp-Arida; Katherine P Yates; Arun J Sanyal; Cynthia D Guy; Anna Mae Diehl Journal: Clin Gastroenterol Hepatol Date: 2012-02-14 Impact factor: 11.382
Authors: David E Kleiner; Elizabeth M Brunt; Mark Van Natta; Cynthia Behling; Melissa J Contos; Oscar W Cummings; Linda D Ferrell; Yao-Chang Liu; Michael S Torbenson; Aynur Unalp-Arida; Matthew Yeh; Arthur J McCullough; Arun J Sanyal Journal: Hepatology Date: 2005-06 Impact factor: 17.425
Authors: Arun J Sanyal; Elizabeth M Brunt; David E Kleiner; Kris V Kowdley; Naga Chalasani; Joel E Lavine; Vlad Ratziu; Arthur McCullough Journal: Hepatology Date: 2011-07 Impact factor: 17.425
Authors: A E Feldstein; P Charatcharoenwitthaya; S Treeprasertsuk; J T Benson; F B Enders; P Angulo Journal: Gut Date: 2009-07-21 Impact factor: 23.059
Authors: Jeannie S Huang; Sarah E Barlow; Ruben E Quiros-Tejeira; Ann Scheimann; Joseph Skelton; David Suskind; Patrika Tsai; Victor Uko; Joshua P Warolin; Stavra A Xanthakos Journal: J Pediatr Gastroenterol Nutr Date: 2013-01 Impact factor: 2.839
Authors: R Ellen Jones; Ann Ming Yeh; Neerajah Kambham; Marwa Abu El Haija; Janey Pratt; Matias Bruzoni Journal: Obes Surg Date: 2020-01 Impact factor: 4.129