Literature DB >> 24676590

[Safety of antirheumatic drug treatment in the elderly].

K Krüger1, A Strangfeld2, C Kneitz3.   

Abstract

Mainly due to the general demographic changes and decreasing mortality in rheumatic diseases based on therapeutic progress, the proportion of older patients treated by rheumatologists is growing. Drug treatment in the elderly, however, harbors certain risks including age-specific pharmacokinetic features and high rates of multimorbidity and polypharmacy resulting in a risk of drug interactions and adherence problems. Nevertheless, older patients suffering from rheumatic diseases ought to be treated with the same intensity and same targets as the younger counterparts. Bearing all these facts in mind it is a balancing act for rheumatologists to find an optimal treatment for the individual elderly patient. Fear of risks should not lead to hesitant use of drugs leaving these patients alone with treatment deficits, as some studies have suggested.

Entities:  

Keywords:  Antirheumatic drugs; Drug interactions; Drug safety; Drug treatment; Elderly patients

Mesh:

Substances:

Year:  2014        PMID: 24676590     DOI: 10.1007/s00393-013-1245-3

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN: 0340-1855            Impact factor:   1.372


  36 in total

1.  [Drug-drug interactions in antirheumatic treatment].

Authors:  K Krüger
Journal:  Z Rheumatol       Date:  2012-04       Impact factor: 1.372

2.  Discontinuation of methotrexate therapy in older patients with newly diagnosed rheumatoid arthritis: analysis of administrative health databases in Québec, Canada.

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Journal:  Drugs Aging       Date:  2008       Impact factor: 3.923

Review 3.  Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials.

Authors:  Donna M Zulman; Jeremy B Sussman; Xisui Chen; Christine T Cigolle; Caroline S Blaum; Rodney A Hayward
Journal:  J Gen Intern Med       Date:  2011-02-01       Impact factor: 5.128

Review 4.  Adherence to medicines in the older-aged with chronic conditions: does intervention by an allied health professional help?

Authors:  Sheila A Doggrell
Journal:  Drugs Aging       Date:  2010-03-01       Impact factor: 3.923

5.  Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte.

Authors:  P Feugier; A Van Hoof; C Sebban; P Solal-Celigny; R Bouabdallah; C Fermé; B Christian; E Lepage; H Tilly; F Morschhauser; P Gaulard; G Salles; A Bosly; C Gisselbrecht; F Reyes; B Coiffier
Journal:  J Clin Oncol       Date:  2005-05-02       Impact factor: 44.544

6.  Drug compliance and unreported drugs in the elderly.

Authors:  A Spagnoli; G Ostino; A D Borga; R D'Ambrosio; P Maggiorotti; E Todisco; W Prattichizzo; L Pia; M Comelli
Journal:  J Am Geriatr Soc       Date:  1989-07       Impact factor: 5.562

7.  Frailty in older adults: evidence for a phenotype.

Authors:  L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2001-03       Impact factor: 6.053

8.  [Comorbidity in rheumatoid arthritis of early onset. Effects on outcome parameters].

Authors:  G Westhoff; C Weber; A Zink
Journal:  Z Rheumatol       Date:  2006-10       Impact factor: 1.372

9.  Drug/drug interaction of common NSAIDs with antiplatelet effect of aspirin in human platelets.

Authors:  Aaruni Saxena; Vishal M Balaramnavar; Thomas Hohlfeld; Anil K Saxena
Journal:  Eur J Pharmacol       Date:  2013-09-25       Impact factor: 4.432

10.  Clinical presentation, burden of disease and treatment in young-onset and late-onset rheumatoid arthritis: a matched-pairs analysis taking age and disease duration into account.

Authors:  Dörte Huscher; Claudia Sengler; Erika Gromnica-Ihle; Sascha Bischoff; Thorsten Eidner; Wolfgang Ochs; Jutta Richter; Angela Zink
Journal:  Clin Exp Rheumatol       Date:  2013-01-09       Impact factor: 4.473

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  1 in total

1.  Elderly psoriatic arthritis patients on TNF-α blockers: results of an Italian multicenter study on minimal disease activity and drug discontinuation rate.

Authors:  Luisa Costa; Ennio Lubrano; Roberta Ramonda; Maria Sole Chimenti; Maristella Vezzù; Fabio M Perrotta; Antonio Del Puente; Rosario Peluso; Paolo Bottiglieri; Mariagrazia Lorenzin; Flavia Sunzini; Md Abud Darda; Ugo Fiocco; Roberto Perricone; Leonardo Punzi; Raffaele Scarpa; Francesco Caso
Journal:  Clin Rheumatol       Date:  2017-06-07       Impact factor: 2.980

  1 in total

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