Literature DB >> 24675520

Zinc transport and diabetes risk.

Ewan Pearson1.   

Abstract

Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk. A rare variant association study has now established the direction of effect, surprisingly showing that loss-of-function mutations in SLC30A8 are protective against diabetes.

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Year:  2014        PMID： 24675520     DOI： 10.1038/ng.2934

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  9 in total

1.  A genome-wide association study identifies novel risk loci for type 2 diabetes.

Authors:  Robert Sladek; Ghislain Rocheleau; Johan Rung; Christian Dina; Lishuang Shen; David Serre; Philippe Boutin; Daniel Vincent; Alexandre Belisle; Samy Hadjadj; Beverley Balkau; Barbara Heude; Guillaume Charpentier; Thomas J Hudson; Alexandre Montpetit; Alexey V Pshezhetsky; Marc Prentki; Barry I Posner; David J Balding; David Meyre; Constantin Polychronakos; Philippe Froguel
Journal:  Nature       Date:  2007-02-11       Impact factor: 49.962

2.  The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance.

Authors:  Motoyuki Tamaki; Yoshio Fujitani; Akemi Hara; Toyoyoshi Uchida; Yoshifumi Tamura; Kageumi Takeno; Minako Kawaguchi; Takahiro Watanabe; Takeshi Ogihara; Ayako Fukunaka; Tomoaki Shimizu; Tomoya Mita; Akio Kanazawa; Mica O Imaizumi; Takaya Abe; Hiroshi Kiyonari; Shintaro Hojyo; Toshiyuki Fukada; Takeshi Kawauchi; Shinya Nagamatsu; Toshio Hirano; Ryuzo Kawamori; Hirotaka Watada
Journal:  J Clin Invest       Date:  2013-09-24       Impact factor: 14.808

3.  Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc.

Authors:  P D Zalewski; S H Millard; I J Forbes; O Kapaniris; A Slavotinek; W H Betts; A D Ward; S F Lincoln; I Mahadevan
Journal:  J Histochem Cytochem       Date:  1994-07       Impact factor: 2.479

4.  Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.

Authors:  Jason Flannick; Gudmar Thorleifsson; Nicola L Beer; Suzanne B R Jacobs; Niels Grarup; Noël P Burtt; Anubha Mahajan; Christian Fuchsberger; Gil Atzmon; Rafn Benediktsson; John Blangero; Don W Bowden; Ivan Brandslund; Julia Brosnan; Frank Burslem; John Chambers; Yoon Shin Cho; Cramer Christensen; Desirée A Douglas; Ravindranath Duggirala; Zachary Dymek; Yossi Farjoun; Timothy Fennell; Pierre Fontanillas; Tom Forsén; Stacey Gabriel; Benjamin Glaser; Daniel F Gudbjartsson; Craig Hanis; Torben Hansen; Astradur B Hreidarsson; Kristian Hveem; Erik Ingelsson; Bo Isomaa; Stefan Johansson; Torben Jørgensen; Marit Eika Jørgensen; Sekar Kathiresan; Augustine Kong; Jaspal Kooner; Jasmina Kravic; Markku Laakso; Jong-Young Lee; Lars Lind; Cecilia M Lindgren; Allan Linneberg; Gisli Masson; Thomas Meitinger; Karen L Mohlke; Anders Molven; Andrew P Morris; Shobha Potluri; Rainer Rauramaa; Rasmus Ribel-Madsen; Ann-Marie Richard; Tim Rolph; Veikko Salomaa; Ayellet V Segrè; Hanna Skärstrand; Valgerdur Steinthorsdottir; Heather M Stringham; Patrick Sulem; E Shyong Tai; Yik Ying Teo; Tanya Teslovich; Unnur Thorsteinsdottir; Jeff K Trimmer; Tiinamaija Tuomi; Jaakko Tuomilehto; Fariba Vaziri-Sani; Benjamin F Voight; James G Wilson; Michael Boehnke; Mark I McCarthy; Pål R Njølstad; Oluf Pedersen; Leif Groop; David R Cox; Kari Stefansson; David Altshuler
Journal:  Nat Genet       Date:  2014-03-02       Impact factor: 38.330

5.  Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.

Authors:  Fabrice Chimienti; Séverine Devergnas; Alain Favier; Michel Seve
Journal:  Diabetes       Date:  2004-09       Impact factor: 9.461

6.  The metabolism of proinsulin and insulin by the liver.

Authors:  A H Rubenstein; L A Pottenger; M Mako; G S Getz; D F Steiner
Journal:  J Clin Invest       Date:  1972-04       Impact factor: 14.808

7.  Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

Authors:  K Kirchhoff; F Machicao; A Haupt; S A Schäfer; O Tschritter; H Staiger; N Stefan; H-U Häring; A Fritsche
Journal:  Diabetologia       Date:  2008-02-09       Impact factor: 10.122

8.  Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Authors:  Tamara J Nicolson; Elisa A Bellomo; Nadeeja Wijesekara; Merewyn K Loder; Jocelyn M Baldwin; Armen V Gyulkhandanyan; Vasilij Koshkin; Andrei I Tarasov; Raffaella Carzaniga; Katrin Kronenberger; Tarvinder K Taneja; Gabriela da Silva Xavier; Sarah Libert; Philippe Froguel; Raphael Scharfmann; Volodymir Stetsyuk; Philippe Ravassard; Helen Parker; Fiona M Gribble; Frank Reimann; Robert Sladek; Stephen J Hughes; Paul R V Johnson; Myriam Masseboeuf; Remy Burcelin; Stephen A Baldwin; Ming Liu; Roberto Lara-Lemus; Peter Arvan; Frans C Schuit; Michael B Wheeler; Fabrice Chimienti; Guy A Rutter
Journal:  Diabetes       Date:  2009-06-19       Impact factor: 9.461

Review 9.  Animal models of GWAS-identified type 2 diabetes genes.

Authors:  Gabriela da Silva Xavier; Elisa A Bellomo; James A McGinty; Paul M French; Guy A Rutter
Journal:  J Diabetes Res       Date:  2013-04-11       Impact factor: 4.011
  9 in total
  11 in total

1.  SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients.

Authors:  Else M Balke; Simke Demeester; DaHae Lee; Pieter Gillard; Robert Hilbrands; Ursule Van de Velde; Bart J Van der Auwera; Zhidong Ling; Bart O Roep; Daniël G Pipeleers; Bart Keymeulen; Frans K Gorus
Journal:  Diabetologia       Date:  2018-04-20       Impact factor: 10.122

Review 2.  Translating genome-wide association findings into new therapeutics for psychiatry.

Authors:  Gerome Breen; Qingqin Li; Bryan L Roth; Patricio O'Donnell; Michael Didriksen; Ricardo Dolmetsch; Paul F O'Reilly; Héléna A Gaspar; Husseini Manji; Christopher Huebel; John R Kelsoe; Dheeraj Malhotra; Alessandro Bertolino; Danielle Posthuma; Pamela Sklar; Shitij Kapur; Patrick F Sullivan; David A Collier; Howard J Edenberg
Journal:  Nat Neurosci       Date:  2016-10-26       Impact factor: 24.884

Review 3.  Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery.

Authors:  Kaixin Zhou; Helle Krogh Pedersen; Adem Y Dawed; Ewan R Pearson
Journal:  Nat Rev Endocrinol       Date:  2016-04-11       Impact factor: 43.330

4.  Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.

Authors:  Chengfeng Merriman; Hua Li; Huilin Li; Dax Fu
Journal:  J Biol Chem       Date:  2018-09-04       Impact factor: 5.157

5.  Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.

Authors:  Kathleen A Bailey; Daniel Savic; Mark Zielinski; Soo-Young Park; Ling-Jia Wang; Piotr Witkowski; Matthew Brady; Manami Hara; Graeme I Bell; Marcelo A Nobrega
Journal:  Hum Mol Genet       Date:  2014-11-14       Impact factor: 6.150

Review 6.  The physiological role of drug transporters.

Authors:  Yu Liang; Siqi Li; Ligong Chen
Journal:  Protein Cell       Date:  2015-03-24       Impact factor: 14.870

Review 7.  Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus.

Authors:  Bo Yi; Gan Huang; Zhi-Guang Zhou
Journal:  Chin Med J (Engl)       Date:  2015-09-05       Impact factor: 2.628

8.  Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules.

Authors:  Sai Yin; Qiuhong Qin; Bing Zhou
Journal:  BMC Biol       Date:  2017-02-14       Impact factor: 7.431

Review 9.  Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research.

Authors:  Ming Hu; Ines Cherkaoui; Shivani Misra; Guy A Rutter
Journal:  Front Endocrinol (Lausanne)       Date:  2020-10-08       Impact factor: 5.555

Review 10.  Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus.

Authors:  Bo Yi; Gan Huang; Zhiguang Zhou
Journal:  J Diabetes Investig       Date:  2016-01-09       Impact factor: 4.232
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