| Literature DB >> 24675377 |
Keru Zhang1, Xing Tang2, Juan Zhang3, Wei Lu3, Xia Lin3, Yu Zhang3, Bin Tian3, Hua Yang3, Haibing He3.
Abstract
In the paper, we begin by describing polyethylene glycol-poly lactic acid-co-glycolic acid (PEG-PLGA) which was chosen as a typical model copolymer for the construction of nano-sized drug delivery systems and also the types of PEG-PLGA copolymers that were eluted. Following this we examine the structure-influenced drug delivery applications including nanoparticles, micelles and hydrogels. After that, the preparation methods for nano-sized delivery systems are presented. In addition, the drug loading mode of PEG-PLGA micelles is divided into three aspects. Finally, the drug release profiles of PEG-PLGA micelles, both in terms of their in vitro and in vivo characteristics, are represented. PEG-PLGA copolymers are very suitable for the construction of micelles as carriers for insoluble drugs. This article reviews the structure and the different structure-influenced applications of PEG-PLGA copolymers, concentrating on the application of PEG-PLGA micelles.Entities:
Keywords: Drug delivery applications; Drug loading; Drug release; PEG–PLGA copolymers; Structure types; Target delivery
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Year: 2014 PMID： 24675377 DOI： 10.1016/j.jconrel.2014.03.026
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776