Ryoko Tajima1, Satoru Kodama2, Miho Hirata1, Chika Horikawa3, Kazuya Fujihara4, Yoko Yachi5, Sakiko Yoshizawa6, Kaoruko Tada Iida1, Hirohito Sone7. 1. Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Japan. 2. Department of Health Management Center, Mito Kyodo General Hospital, Japan; Department of Internal Medicine, Niigata University Faculty of Medicine, Japan. 3. Department of Internal Medicine, Niigata University Faculty of Medicine, Japan; Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Japan. 4. Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, Japan. 5. Department of Nutrition and Food Science, Graduate School of Humanities and Sciences, Ochanomizu University, Japan; Department of Internal Medicine, Niigata University Faculty of Medicine, Japan. 6. Department of Internal Medicine, Niigata University Faculty of Medicine, Japan. 7. Department of Internal Medicine, Niigata University Faculty of Medicine, Japan. Electronic address: sone@med.niigata-u.ac.jp.
Abstract
BACKGROUND & AIMS: Some foods rich in cholesterol are associated with high risk of type 2 diabetes (T2D). To confirm the association between dietary cholesterol intake and T2D risk, we performed a meta-analysis of observational studies. METHODS: We searched for longitudinal studies that provided data on the relative risk (RR) for T2D in relation to the cholesterol intake level using MEDLINE (from 1950 for July 10, 2013) and EMBASE (from 1974 to July 10, 2013). The RR for the highest vs. lowest cholesterol intake category or for an increment of 100 mg/day in cholesterol consumption was pooled with an inverse-variance method. RESULTS: Five studies met the inclusion criteria. Compared with the lowest category, the highest category had a significantly higher association with T2D risk (RR [95% confidence interval (CI)], 1.25 [1.16-1.36]). The pooled RR for a 100-mg/day increment was also significant (RR [95% CI], 1.11 [1.06-1.15]). CONCLUSION: Current meta-analysis suggested that high intake of cholesterol was positively associated with future T2D risk.
BACKGROUND & AIMS: Some foods rich in cholesterol are associated with high risk of type 2 diabetes (T2D). To confirm the association between dietary cholesterol intake and T2D risk, we performed a meta-analysis of observational studies. METHODS: We searched for longitudinal studies that provided data on the relative risk (RR) for T2D in relation to the cholesterol intake level using MEDLINE (from 1950 for July 10, 2013) and EMBASE (from 1974 to July 10, 2013). The RR for the highest vs. lowest cholesterol intake category or for an increment of 100 mg/day in cholesterol consumption was pooled with an inverse-variance method. RESULTS: Five studies met the inclusion criteria. Compared with the lowest category, the highest category had a significantly higher association with T2D risk (RR [95% confidence interval (CI)], 1.25 [1.16-1.36]). The pooled RR for a 100-mg/day increment was also significant (RR [95% CI], 1.11 [1.06-1.15]). CONCLUSION: Current meta-analysis suggested that high intake of cholesterol was positively associated with future T2D risk.
Authors: James A Greenberg; Xinyin Jiang; Lesley F Tinker; Linda G Snetselaar; Nazmus Saquib; Aladdin H Shadyab Journal: Am J Clin Nutr Date: 2021-07-01 Impact factor: 7.045