Xu-Dong Xu1, Su-Xuan Liu1, Xin Liu2, Yan Chen3, Ling Li4, Bai-Ming Qu5, Zhi-Yong Wu6, Dai-Fu Zhang7, Xian-Xian Zhao8, Yong-Wen Qin9. 1. Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China. 2. Department of Cardiology, Henan Provincial Chest Hospital, Zhengzhou 450008, PR China. 3. Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, PR China. 4. Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China. 5. Department of Cardiology, Zhejiang Provincial People's Hospital, Hangzhou 310014, PR China. 6. Department of Cardiology, Fujian Provincial Hospital, Fuzhou 350001, PR China. 7. Department of Cardiology, Shanghai East Hospital, Shanghai 200120, PR China. 8. Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China. Electronic address: xianxianz2010@163.com. 9. Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China. Electronic address: qywsmmu@163.com.
Abstract
BACKGROUND: Surgical repair is an effective method to treat ventricular septal defect (VSD) complicating acute myocardial infarction (AMI). However, the mortality rate remains high. This study was designed to assess the immediate and mid-term results of transcatheter closure of postinfarct muscular VSDs. METHODS: Data were retrospectively collected from 42 AMI patients who underwent attempted transcatheter VSD closure between 2008 and 2012 in seven heart centers of China. RESULTS: Nine patients underwent emergent VSD closure in the acute phase (within two weeks from VSD) while the others underwent elective closure. The time between VSD occurrence and closure in emergency group and elective group was 7.7 ± 2.3 days and 35 ± 14.5 days, respectively (p<0.01). The percentage of procedure success in the emergency group and elective group was 77.8% (7/9) and 97% (32/33), respectively (p=0.048). The hospital mortality was higher for emergent closure in comparison to elective closure (66.7% vs. 6.1%, p<0.01). During a median follow-up of 25 months (0-58 months), two patients died at 8 and 29 months, respectively, and no serious complications occurred in other patients. CONCLUSION: Interventional postinfarct VSD closure is a safe and effective approach that can be performed with a high procedural success rate, with favorable outcomes if it can be undertaken >14 days postinfarct.
BACKGROUND: Surgical repair is an effective method to treat ventricular septal defect (VSD) complicating acute myocardial infarction (AMI). However, the mortality rate remains high. This study was designed to assess the immediate and mid-term results of transcatheter closure of postinfarct muscular VSDs. METHODS: Data were retrospectively collected from 42 AMI patients who underwent attempted transcatheter VSD closure between 2008 and 2012 in seven heart centers of China. RESULTS: Nine patients underwent emergent VSD closure in the acute phase (within two weeks from VSD) while the others underwent elective closure. The time between VSD occurrence and closure in emergency group and elective group was 7.7 ± 2.3 days and 35 ± 14.5 days, respectively (p<0.01). The percentage of procedure success in the emergency group and elective group was 77.8% (7/9) and 97% (32/33), respectively (p=0.048). The hospital mortality was higher for emergent closure in comparison to elective closure (66.7% vs. 6.1%, p<0.01). During a median follow-up of 25 months (0-58 months), two patients died at 8 and 29 months, respectively, and no serious complications occurred in other patients. CONCLUSION: Interventional postinfarct VSD closure is a safe and effective approach that can be performed with a high procedural success rate, with favorable outcomes if it can be undertaken >14 days postinfarct.