Suzanne B Evans1, Babita Panigrahi2, Veronika Northrup3, Joseph Patterson2, Drew E Baldwin4, Susan A Higgins5, Meena S Moran5. 1. Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut. Electronic address: suzanne.evans@yale.edu. 2. Yale University School of Medicine, New Haven, Connecticut. 3. Department of Biostatistics, Yale University, New Haven, Connecticut. 4. Department of Cardiology, The Heart Institute at Virginia Mason, Seattle, Washington. 5. Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.
Abstract
PURPOSE: To evaluate the dose to the left anterior descending artery in patients receiving left-sided tangential breast radiation. METHODS AND MATERIALS: The study cohort consisted of 50 left-sided breast cancer patients who were sequentially simulated at our institution. The heart and left anterior descending (LAD) artery were contoured from its origin on the left main coronary artery down to the last visible segment of the vessel. Detailed dosimetry of the heart and LAD artery were obtained and analyzed. RESULTS: Excellent correlation between the dose to the heart and LAD artery was discovered. The mean LAD dose was 17.98 Gy. The mean dose to the proximal LAD was 2.46 Gy. The median V25 was 2.91% and the mean heart dose 3.10 Gy. For every 100 cGy increase in mean heart dose, mean LAD dose increased by 4.82 Gy. For every percent increase in the heart V10 and V25, there was a 2.23 Gy and 2.77 Gy increase in mean LAD dose, respectively. For every percent increase of heart V25, a 5.6% increase in the LAD V20 was demonstrated. CONCLUSIONS: The LAD artery dose correlates very closely with all of the commonly measured heart dose constraints, and does not need to be contoured separately when standard tangential borders are used. Incidental LAD artery doses remain with supine breast tangential radiation therapy.
PURPOSE: To evaluate the dose to the left anterior descending artery in patients receiving left-sided tangential breast radiation. METHODS AND MATERIALS: The study cohort consisted of 50 left-sided breast cancerpatients who were sequentially simulated at our institution. The heart and left anterior descending (LAD) artery were contoured from its origin on the left main coronary artery down to the last visible segment of the vessel. Detailed dosimetry of the heart and LAD artery were obtained and analyzed. RESULTS: Excellent correlation between the dose to the heart and LAD artery was discovered. The mean LAD dose was 17.98 Gy. The mean dose to the proximal LAD was 2.46 Gy. The median V25 was 2.91% and the mean heart dose 3.10 Gy. For every 100 cGy increase in mean heart dose, mean LAD dose increased by 4.82 Gy. For every percent increase in the heart V10 and V25, there was a 2.23 Gy and 2.77 Gy increase in mean LAD dose, respectively. For every percent increase of heart V25, a 5.6% increase in the LAD V20 was demonstrated. CONCLUSIONS: The LAD artery dose correlates very closely with all of the commonly measured heart dose constraints, and does not need to be contoured separately when standard tangential borders are used. Incidental LAD artery doses remain with supine breast tangential radiation therapy.
Authors: Ji Hyeon Joo; Su Ssan Kim; Seung Do Ahn; Jungwon Kwak; Chiyoung Jeong; Sei-Hyun Ahn; Byung-Ho Son; Jong Won Lee Journal: Radiat Oncol Date: 2015-12-30 Impact factor: 3.481
Authors: Y Jessica Huang; Alexis Harrison; Vikren Sarkar; Prema Rassiah-Szegedi; Hui Zhao; Martin Szegedi; Long Huang; Brent Wilson; David K Gaffney; Bill J Salter Journal: Adv Radiat Oncol Date: 2016-04-26
Authors: María Adela Poitevin-Chacón; Rubí Ramos-Prudencio; José Alfonso Rumoroso-García; Alejandro Rodríguez-Laguna; Julio Cesar Martínez-Robledo Journal: Rep Pract Oncol Radiother Date: 2019-12-19