Kathryn Phillips1, Kathleen Keane2, Barbara E Wolfe3. 1. Fairfield University, Fairfield, CT. Electronic address: Kphillips1@fairfield.edu. 2. Boston College, Chestnut Hill, MA; Richards 1, Maine Medical Center, Portland, ME. Electronic address: keanekd@bc.edu. 3. Boston College, Chestnut Hill, MA. Electronic address: Barabara.wolfe.1@bc.edu.
Abstract
INTRODUCTION: Currently, there is limited understanding of the etiology of BN. While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic factor (BDNF), a potential biomarker linked to eating and weight disorders, is one factor of recent investigation. This paper examined studies comparing BDNF blood levels in BN to healthy control (HC) subjects. METHODS: A systematic review of the literature was conducted utilizing five databases (PubMed, CINAHL, EMBASE, PsycINFO, and Medline). Key terms included eating disorders, BDNF, and bulimia nervosa. CONCLUSIONS: BDNF blood levels appear lower in BN than in HC subjects; however, studies are needed to examine the influence of possible correlates including symptom severity, mood, medications, exercise, and substance use.
INTRODUCTION: Currently, there is limited understanding of the etiology of BN. While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic factor (BDNF), a potential biomarker linked to eating and weight disorders, is one factor of recent investigation. This paper examined studies comparing BDNF blood levels in BN to healthy control (HC) subjects. METHODS: A systematic review of the literature was conducted utilizing five databases (PubMed, CINAHL, EMBASE, PsycINFO, and Medline). Key terms included eating disorders, BDNF, and bulimia nervosa. CONCLUSIONS:BDNF blood levels appear lower in BN than in HC subjects; however, studies are needed to examine the influence of possible correlates including symptom severity, mood, medications, exercise, and substance use.
Authors: Jonas L Steinhäuser; Joseph A King; Friederike I Tam; Maria Seidel; Ronald Biemann; Marie-Louis Wronski; Daniel Geisler; Veit Roessner; Stefan Ehrlich Journal: Nutrients Date: 2021-01-29 Impact factor: 5.717