| Literature DB >> 24673642 |
Abstract
What do complex networks, such as those found in cancer cells, airplane flight patterns and the Internet have in common? A remarkable robustness with a surprising vulnerability. Complex networks follow remarkably similar patterns across seemingly unconnected fields, and it is possible that cancer researchers could thus learn from the advances in complex network theory. Very limited, yet coordinated, specific targeting of the most critical parts of a network can have dramatically outsized effects. "At times, our strengths propel us so far forward we can no longer endure our weaknesses and perish from them." Nietzsche.Entities:
Keywords: cancer; combination therapy; complexity; robustness; scale free networks; small molecule inhibitors; targeted therapy
Mesh:
Year: 2015 PMID: 24673642 DOI: 10.2217/fon.14.49
Source DB: PubMed Journal: Future Oncol ISSN: 1479-6694 Impact factor: 3.404