Lei Wang1, Tianwen Gao, Gang Wang. 1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.
Abstract
BACKGROUND: Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma. METHODS: We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1). RESULTS: The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1. CONCLUSION: Our results suggest that spindle cell hemangioma is a lymphatic malformation.
BACKGROUND: Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma. METHODS: We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1). RESULTS: The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1. CONCLUSION: Our results suggest that spindle cell hemangioma is a lymphatic malformation.
Authors: Lukasz A Adamczyk; Kristiana Gordon; Ivana Kholová; Lorine B Meijer-Jorna; Niklas Telinius; Patrick J Gallagher; Allard C van der Wal; Ulrik Baandrup Journal: Virchows Arch Date: 2016-05-12 Impact factor: 4.064