INTRODUCTION: Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects long-term graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary. PATIENTS AND METHODS: We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%). RESULTS: Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had significantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining five patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis. CONCLUSIONS: Recurrent PSC significantly affects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective effect against rPSC.
INTRODUCTION: Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects long-term graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary. PATIENTS AND METHODS: We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%). RESULTS: Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had significantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining five patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis. CONCLUSIONS: Recurrent PSC significantly affects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective effect against rPSC.
Authors: Alonso Vera; Shazma Moledina; Bridget Gunson; Stefan Hubscher; Darius Mirza; Simon Olliff; James Neuberger Journal: Lancet Date: 2002-12-14 Impact factor: 79.321
Authors: I W Graziadei; R H Wiesner; K P Batts; P J Marotta; N F LaRusso; M K Porayko; J E Hay; G J Gores; M R Charlton; J Ludwig; J J Poterucha; J L Steers; R A Krom Journal: Hepatology Date: 1999-04 Impact factor: 17.425
Authors: U Ołdakowska-Jedynak; M Nowak; K Mucha; B Foroncewicz; P Nyckowski; K Zieniewicz; B Ziarkiewicz-Wróblewska; W Patkowski; B Górnicka; A Paczkowska; B Michałowicz; T Pilecki; J Pawlak; M Krawczyk; L Paczek Journal: Transplant Proc Date: 2006 Jan-Feb Impact factor: 1.066
Authors: Urmila Khettry; Andrew Keaveny; Atoussa Goldar-Najafi; W David Lewis; Elizabeth A Pomfret; James J Pomposelli; Roger L Jenkins; Fredric D Gordon Journal: Hum Pathol Date: 2003-11 Impact factor: 3.466
Authors: Jeffrey Campsen; Michael A Zimmerman; James F Trotter; Michael Wachs; Thomas Bak; Tracy Steinberg; Igal Kam Journal: Liver Transpl Date: 2008-02 Impact factor: 5.799
Authors: Edward Alabraba; Peter Nightingale; Bridget Gunson; Stefan Hubscher; Simon Olliff; Darius Mirza; James Neuberger Journal: Liver Transpl Date: 2009-03 Impact factor: 5.799
Authors: Bettina M Buchholz; Panagis M Lykoudis; Reena Ravikumar; Joerg M Pollok; Giuseppe K Fusai Journal: World J Gastroenterol Date: 2018-07-28 Impact factor: 5.742
Authors: Jacqueline B Henson; Yuval A Patel; Julius M Wilder; Jiayin Zheng; Shein-Chung Chow; Lindsay Y King; Andrew J Muir Journal: Dig Dis Sci Date: 2017-04-08 Impact factor: 3.199
Authors: Iris C Steenstraten; Kerem Sebib Korkmaz; Palak J Trivedi; Akin Inderson; Bart van Hoek; Mar D M Rodriguez Girondo; P W Jeroen Maljaars Journal: Aliment Pharmacol Ther Date: 2019-02-10 Impact factor: 8.171