Literature DB >> 24671904

Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease.

Gard F T Svingen1, Hall Schartum-Hansen2, Per M Ueland3, Eva R Pedersen4, Reinhard Seifert5, Marta Ebbing6, Kaare H Bønaa7, Gunnar Mellgren8, Dennis W T Nilsen9, Jan E Nordrehaug4, Jannike Øyen10, Ottar Nygård11.   

Abstract

AIM: To investigate whether plasma dimethylglycine was associated with and improved risk prediction of mortality among patients with coronary heart disease (CHD).
METHODS: By Cox modelling, we explored the association between plasma dimethylglycine and mortality in two independent cohorts of patients with suspected stable angina pectoris (SAP) (n = 4156) and acute myocardial infarction (AMI) (n = 3733). We also assessed any improvement in risk prediction by adding plasma dimethylglycine to established CHD risk factors.
RESULTS: Median follow-up time was 4.7 and 7.0 years among patients with SAP and AMI, respectively. Across both cohorts, elevated plasma dimethylglycine levels were linearly associated with increased risk of all-cause mortality (age and gender adjusted hazard ratios (95% confidence interval, CI) were 1.72 (1.21-2.46) and 1.76 (1.42-2.18) when comparing the fourth versus the first plasma dimethylglycine quartile in patients with SAP and AMI, respectively). There was a particularly strong risk association between plasma dimethylglycine and cardiovascular, as compared with non-cardiovascular, mortality (age and gender adjusted hazard ratios (95% CI) 1.94 (1.21-3.11) and 1.43 (0.83-2.47) among patients with SAP and 1.97 (1.50-2.59) and 1.44 (1.02-2.04) among patients with AMI, respectively). The relationship between dimethylglycine and all-cause and cardiovascular mortality was only slightly attenuated in analyses adjusted for established CHD risk factors. Plasma dimethylglycine also improved risk prediction for all-cause and cardiovascular mortality, and especially among patients with AMI.
CONCLUSIONS: Elevated plasma dimethylglycine was associated with and improved risk prediction of mortality in patients with suspected or verified CHD. This relationship was stronger for death from cardiovascular, as compared with non-cardiovascular, causes. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Entities:  

Keywords:  Angina pectoris; acute myocardial infarction; coronary heart disease; dimethylglycine; mortality

Mesh：

Substances：

Year:  2014        PMID： 24671904     DOI： 10.1177/2047487314529351

Source DB:  PubMed          Journal:  Eur J Prev Cardiol        ISSN： 2047-4873            Impact factor:   7.804


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