Literature DB >> 2467137

A double-blind crossover comparison of amlodipine and placebo added to captopril in moderate to severe hypertension.

D Maclean1, E T Mitchell, R G Wilcox, P Walker, H M Tyler.   

Abstract

Amlodipine 10 mg once daily added to captopril 25 mg twice daily for 4 weeks in patients with moderate to severe hypertension significantly improved blood pressure control (by -18/-12 and -20/-12 mm Hg for supine and standing systolic/diastolic pressures respectively, p less than 0.001). Few side effects related to amlodipine were noted and none was serious.

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Year:  1988        PMID: 2467137     DOI: 10.1097/00005344-198812007-00019

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN: 0160-2446            Impact factor:   3.105


  1 in total

Review 1.  Calcium channel antagonists. Part V: Second-generation agents.

Authors:  L H Opie
Journal:  Cardiovasc Drugs Ther       Date:  1988-07       Impact factor: 3.727

  1 in total

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