C T Fiske1, F-X Yan2, Y Hirsch-Moverman3, T R Sterling1, M R Reichler2. 1. Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. 2. Centers for Disease Control and Prevention, Atlanta, Georgia, USA. 3. Charles P Felton National Tuberculosis Center, International Center for AIDS Care and Treatment Programs, Mailman School of Public Health, Columbia University, New York, New York, USA.
Abstract
OBJECTIVE: 1) To characterize risk factors for non-completion of latent tuberculous infection treatment (LTBIT), and 2) to assess the impact of LTBIT regimens on subsequent risk of tuberculosis (TB). METHODS: Close contacts of adults aged ⩾15 years with pulmonary TB were prospectively enrolled in a multi-center study in the United States and Canada from January 2002 to December 2006. Close contacts of TB patients were screened and cross-matched with TB registries to identify those who developed active TB. RESULTS: Of 3238 contacts screened, 1714 (53%) were diagnosed with LTBI. Preventive treatment was recommended in 1371 (80%); 1147 (84%) initiated treatment, of whom 723 (63%) completed it. In multivariate analysis, study site, initial interview sites other than a home or health care setting and isoniazid preventive treatment (IPT) were significantly associated with non-completion of LTBIT. Fourteen TB cases were identified in contacts, all of whom initiated IPT: two TB cases among persons who received ⩾6 months of IPT (66 cases/100 000 person-years [py]), and nine among those who received 0-5 months (median 2 months) of IPT (792 cases/100 000 py, P < 0.001); data on duration of IPT were not available for three cases. CONCLUSION: Only 53% (723/1371) of close contacts for whom IPT was recommended actually completed treatment. Close contacts were significantly less likely to complete LTBIT if they took IPT. Less than 6 months of IPT was associated with increased risk of active TB.
OBJECTIVE: 1) To characterize risk factors for non-completion of latent tuberculous infection treatment (LTBIT), and 2) to assess the impact of LTBIT regimens on subsequent risk of tuberculosis (TB). METHODS: Close contacts of adults aged ⩾15 years with pulmonary TB were prospectively enrolled in a multi-center study in the United States and Canada from January 2002 to December 2006. Close contacts of TB patients were screened and cross-matched with TB registries to identify those who developed active TB. RESULTS: Of 3238 contacts screened, 1714 (53%) were diagnosed with LTBI. Preventive treatment was recommended in 1371 (80%); 1147 (84%) initiated treatment, of whom 723 (63%) completed it. In multivariate analysis, study site, initial interview sites other than a home or health care setting and isoniazid preventive treatment (IPT) were significantly associated with non-completion of LTBIT. Fourteen TB cases were identified in contacts, all of whom initiated IPT: two TB cases among persons who received ⩾6 months of IPT (66 cases/100 000 person-years [py]), and nine among those who received 0-5 months (median 2 months) of IPT (792 cases/100 000 py, P < 0.001); data on duration of IPT were not available for three cases. CONCLUSION: Only 53% (723/1371) of close contacts for whom IPT was recommended actually completed treatment. Close contacts were significantly less likely to complete LTBIT if they took IPT. Less than 6 months of IPT was associated with increased risk of active TB.
Authors: Taraz Samandari; Tefera B Agizew; Samba Nyirenda; Zegabriel Tedla; Thabisa Sibanda; Nong Shang; Barudi Mosimaneotsile; Oaitse I Motsamai; Lorna Bozeman; Margarett K Davis; Elizabeth A Talbot; Themba L Moeti; Howard J Moffat; Peter H Kilmarx; Kenneth G Castro; Charles D Wells Journal: Lancet Date: 2011-04-12 Impact factor: 79.321
Authors: Neil A Martinson; Grace L Barnes; Lawrence H Moulton; Reginah Msandiwa; Harry Hausler; Malathi Ram; James A McIntyre; Glenda E Gray; Richard E Chaisson Journal: N Engl J Med Date: 2011-07-07 Impact factor: 91.245
Authors: Valeria Saraceni; Antonio Guilherme Pacheco; Jonathan E Golub; Vitoria Vellozo; Bonnie S King; Solange C Cavalcante; Lois Eldred; Richard E Chaisson; Betina Durovni Journal: Braz J Infect Dis Date: 2011 May-Jun Impact factor: 1.949
Authors: Timothy R Sterling; M Elsa Villarino; Andrey S Borisov; Nong Shang; Fred Gordin; Erin Bliven-Sizemore; Judith Hackman; Carol Dukes Hamilton; Dick Menzies; Amy Kerrigan; Stephen E Weis; Marc Weiner; Diane Wing; Marcus B Conde; Lorna Bozeman; C Robert Horsburgh; Richard E Chaisson Journal: N Engl J Med Date: 2011-12-08 Impact factor: 91.245
Authors: Anna K Person; Michela L M Blain; Helen Jiang; Petra W Rasmussen; Jason E Stout Journal: Telemed J E Health Date: 2011-04-02 Impact factor: 3.536
Authors: Jiehui Li; Suzanne M Marks; Cynthia R Driver; Francisco A Diaz; Alejandro F Castro; Annette Figueroa de Regner; Aurelia E Gibson; Kinta Dokubo-Okereke; Sonal S Munsiff Journal: J Public Health Manag Pract Date: 2007 May-Jun
Authors: Mary R Reichler; Randall Reves; Sarah Bur; Josie Ford; Virginia Thompson; Bonita Mangura; Ida M Onorato; Sarah E Valway Journal: South Med J Date: 2002-04 Impact factor: 0.954
Authors: Mary R Reichler; Randall Reves; Sarah Bur; Virginia Thompson; Bonita T Mangura; Josie Ford; Sarah E Valway; Ida M Onorato Journal: JAMA Date: 2002-02-27 Impact factor: 56.272
Authors: Mary R Reichler; Awal Khan; Timothy R Sterling; Hui Zhao; Bin Chen; Yan Yuan; Joyce Moran; James McAuley; Bonita Mangura Journal: Clin Infect Dis Date: 2020-04-10 Impact factor: 9.079
Authors: S Swindells; M Siccardi; S E Barrett; D B Olsen; J A Grobler; A T Podany; E Nuermberger; P Kim; C E Barry; A Owen; D Hazuda; C Flexner Journal: Int J Tuberc Lung Dis Date: 2018-02-01 Impact factor: 2.373
Authors: Susan Swindells; Ritesh Ramchandani; Amita Gupta; Constance A Benson; Jorge Leon-Cruz; Noluthando Mwelase; Marc A Jean Juste; Javier R Lama; Javier Valencia; Ayotunde Omoz-Oarhe; Khuanchai Supparatpinyo; Gaerolwe Masheto; Lerato Mohapi; Rodrigo O da Silva Escada; Sajeeda Mawlana; Peter Banda; Patrice Severe; James Hakim; Cecilia Kanyama; Deborah Langat; Laura Moran; Janet Andersen; Courtney V Fletcher; Eric Nuermberger; Richard E Chaisson Journal: N Engl J Med Date: 2019-03-14 Impact factor: 91.245
Authors: Flávia Patussi Correia Sacchi; Mariana Bento Tatara; Camila Camioli de Lima; Liliane Ferreia da Silva; Eunice Atsuko Cunha; Vera Simonsen; Lucilaine Ferrazoli; Harrison Magdinier Gomes; Sidra Ezidio Gonçalves Vasconcellos; Philip Noel Suffys; Jason R Andrews; Julio Croda Journal: Am J Trop Med Hyg Date: 2017-11-30 Impact factor: 2.345
Authors: Sean M Cavany; Tom Sumner; Emilia Vynnycky; Clare Flach; Richard G White; H Lucy Thomas; Helen Maguire; Charlotte Anderson Journal: Thorax Date: 2017-04-07 Impact factor: 9.139
Authors: Mary R Reichler; Awal Khan; Yan Yuan; Bin Chen; James McAuley; Bonita Mangura; Timothy R Sterling Journal: Clin Infect Dis Date: 2020-10-23 Impact factor: 9.079
Authors: D Thindwa; P MacPherson; A T Choko; M Khundi; R Sambakunsi; L G Ngwira; T Kalua; E L Webb; E L Corbett Journal: Int J Tuberc Lung Dis Date: 2018-03-01 Impact factor: 2.373