| Literature DB >> 24670022 |
Hayato Yamauchi1, Shinji Sakurai, Ritsuko Tsukagoshi, Masaki Suzuki, Yuichi Tabe, Takaharu Fukasawa, Shinsuke Kiriyama, Minoru Fukuchi, Hiroshi Naitoh, Hiroyuki Kuwano.
Abstract
Malignant tumors with mixed glandular and neuroendocrine characteristics with at least 30% of each component are classified as mixed adenoneuroendocrine carcinoma (MANEC) by the World Health Organization 2010 classification. We report here a case of very well-differentiated adenocarcinoma accompanied by carcinoid tumor, categorized as MANEC. A 41-year-old Japanese man was clinically diagnosed with ascending colon cancer and underwent right hemicolectomy. Using an immunohistologic technique, the pathologic diagnosis was very well-differentiated adenocarcinoma accompanied by carcinoid tumor and marked eosinophil infiltration, which was categorized as MANEC. By immunohistochemical analysis, tumor cells of the carcinoid component exhibited very low proliferation activity. Our case was thought to be MANEC without high malignant potential. MANEC as per the World Health Organization 2010 classification seems to include tumors with diverse grades of malignancy, and it might need to have subclassifications according to the malignancy potential of the tumor cells.Entities:
Mesh：
Year: 2014 PMID： 24670022 PMCID： PMC3968838 DOI： 10.9738/INTSURG-D-13-00041.1
Source DB: PubMed Journal: Int Surg ISSN： 0020-8868