BACKGROUND AND AIMS: Vitamin D deficiency has been observed in a wide range of medical conditions including Crohn's disease (CD). We aimed to assess whether CD patients have lower vitamin D levels than healthy controls, and to determine risk factors for vitamin D deficiency. METHODS: 25(OH)D was measured by chemiluminescent immunoassay in serum obtained from 101 CD patients and 41 controls. Demographics, sunlight exposure, dietary vitamin D intake, comorbidities and medication were recorded using validated questionnaires. In CD patients the Harvey-Bradshaw index, Montreal classification and surgical resections were also evaluated. 25(OH)D levels of > 75 nmol/L, between 50 and 75 nmol/L and < 50 nmol/L were considered as normal, suboptimal and deficient, respectively. RESULTS: Vitamin D levels were rather low but comparable among CD patients and controls (mean 25(OH)D 51.6 nmol/L(± 26.6) in CD, and 60.8 nmol/L(± 27.6) in controls. Multivariate regression analysis revealed BMI, sun protection behaviour, non-Caucasian ethnicity, no use of tanning beds, and no holidays in the last year as significantly associated with serum 25(OH)D levels in CD patients (R=0.62). In the control group no statistically significant factors were identified that had an impact on 25(OH)D serum levels. CONCLUSIONS: Vitamin D deficiency is common in CD patients, but also in healthy controls. Appropriate vitamin D screening should be advised in patients with CD. Moreover, the positive effect of sunlight on the vitamin D status should be discussed with CD patients, but this should be balanced against the potential risk of developing melanomas, especially in patients using thiopurines.
BACKGROUND AND AIMS: Vitamin D deficiency has been observed in a wide range of medical conditions including Crohn's disease (CD). We aimed to assess whether CDpatients have lower vitamin D levels than healthy controls, and to determine risk factors for vitamin D deficiency. METHODS: 25(OH)D was measured by chemiluminescent immunoassay in serum obtained from 101 CDpatients and 41 controls. Demographics, sunlight exposure, dietary vitamin D intake, comorbidities and medication were recorded using validated questionnaires. In CDpatients the Harvey-Bradshaw index, Montreal classification and surgical resections were also evaluated. 25(OH)D levels of > 75 nmol/L, between 50 and 75 nmol/L and < 50 nmol/L were considered as normal, suboptimal and deficient, respectively. RESULTS:Vitamin D levels were rather low but comparable among CDpatients and controls (mean 25(OH)D 51.6 nmol/L(± 26.6) in CD, and 60.8 nmol/L(± 27.6) in controls. Multivariate regression analysis revealed BMI, sun protection behaviour, non-Caucasian ethnicity, no use of tanning beds, and no holidays in the last year as significantly associated with serum 25(OH)D levels in CDpatients (R=0.62). In the control group no statistically significant factors were identified that had an impact on 25(OH)D serum levels. CONCLUSIONS:Vitamin D deficiency is common in CDpatients, but also in healthy controls. Appropriate vitamin D screening should be advised in patients with CD. Moreover, the positive effect of sunlight on the vitamin D status should be discussed with CDpatients, but this should be balanced against the potential risk of developing melanomas, especially in patients using thiopurines.
Authors: M Bendix; A Dige; B Deleuran; J F Dahlerup; S P Jørgensen; L E Bartels; L B Husted; T Harsløf; B Langdahl; J Agnholt Journal: Clin Exp Immunol Date: 2015-05-05 Impact factor: 4.330
Authors: Toufic A Kabbani; Ioannis E Koutroubakis; Robert E Schoen; Claudia Ramos-Rivers; Nilesh Shah; Jason Swoger; Miguel Regueiro; Arthur Barrie; Marc Schwartz; Jana G Hashash; Leonard Baidoo; Michael A Dunn; David G Binion Journal: Am J Gastroenterol Date: 2016-03-08 Impact factor: 10.864
Authors: Mia Bendix; Stinne Greisen; Anders Dige; Christian L Hvas; Nina Bak; Søren P Jørgensen; Jens F Dahlerup; Bent Deleuran; Jørgen Agnholt Journal: Oncotarget Date: 2017-04-11