| Literature DB >> 24666363 |
Huan Liu1, Guangde Jiang, Xixian Pan, Xiaolong Wan, Yisheng Lai, Dawei Ma, Weiqing Xie.
Abstract
Highly asymmetric bromocyclization of tryptophol by using chiral anionic phase-transfer catalyst and DABCO-derived brominating reagent is described. Optimization of the reaction conditions revealed that the reaction rate was accelerated together with improvement of enantioselectivity by addition of catalytic DABCO-derived brominating reagent. From tryptophol, 3-bromofuroindoline could be directly obtained in excellent enantioselectivities by employing this novel methodology.Entities:
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Year: 2014 PMID： 24666363 DOI： 10.1021/ol5004109
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005