Literature DB >> 24666327

Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208.

Wen Ai1, Xiu-Ping Lin, Zhengchao Tu, Xin-Peng Tian, Xin Lu, Fredimoses Mangaladoss, Zhi-Long Zhong, Yonghong Liu.   

Abstract

Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 μM.

Entities:  

Keywords:  COX-2; Streptomyces axinellae; inhibitor

Mesh：

Substances：

Year:  2014        PMID： 24666327     DOI： 10.1080/14786419.2014.891204

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  5 in total

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Authors:  Jeysson Sánchez-Suárez; Ericsson Coy-Barrera; Luisa Villamil; Luis Díaz
Journal:  Molecules       Date:  2020-07-15       Impact factor: 4.411
  5 in total

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