Literature DB >> 2466513

E-type prostaglandins but not iloprost inhibit platelet activating factor-induced generation of leukotriene B4 by human polymorphonuclear leukocytes.

P Ney1, K Schrör.   

Abstract

1. Platelet-activating factor (Paf) was found to stimulate leukotriene B4 release from human polymorphonuclear leukocytes (PMN). This stimulation was considerably enhanced in the presence of small amounts of exogenous arachidonic acid. 2. Prostaglandin E2 (PGE2) and PGE1 (0.1-10 microM) inhibited this reaction dose-dependently. No inhibition was seen with iloprost at these concentrations. 3. The data suggest that E prostaglandins are potent inhibitors of Paf-induced leukotriene generation by human PMNs and thus may serve as local factors controlling Paf-mediated inflammatory reactions.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2466513      PMCID： PMC1854312          DOI： 10.1111/j.1476-5381.1989.tb11799.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  26 in total

1.  The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine.

Authors:  R J Gryglewski; A Szczeklik; M Wandzilak
Journal:  Biochem Pharmacol       Date:  1987-12-15       Impact factor: 5.858

2.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

3.  Leukotriene B: a potential mediator of inflammation.

Authors:  M J Smith; A W Ford-Hutchinson; M A Bray
Journal:  J Pharm Pharmacol       Date:  1980-07       Impact factor: 3.765

4.  Distinction between prostaglandin E2 and prostacyclin as inhibitors of granulmoatous inflammation.

Authors:  M J Parnham; I L Bonta; M J Adolfs
Journal:  J Pharm Pharmacol       Date:  1979-08       Impact factor: 3.765

5.  Human neutrophil-derived platelet activating factor.

Authors:  G Z Lotner; J M Lynch; S J Betz; P M Henson
Journal:  J Immunol       Date:  1980-02       Impact factor: 5.422

6.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.

Authors:  P Borgeat; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

7.  Effect of prostaglandins E1, E2 and F2alpha on neutrophil aggregation.

Authors:  J T O'Flaherty; D L Kreutzer; P A Ward
Journal:  Prostaglandins       Date:  1979-02

8.  Time-dependent stimulatory and inhibitory effects of prostaglandin E1 on exudative and tissue components of granulomatous inflammation in rats.

Authors:  I L Bonta; M J Parnham
Journal:  Br J Pharmacol       Date:  1979-03       Impact factor: 8.739

9.  Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.

Authors:  L T Williams; R Snyderman; M C Pike; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

10.  Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

Authors:  J O Shaw; R N Pinckard; K S Ferrigni; L M McManus; D J Hanahan
Journal:  J Immunol       Date:  1981-09       Impact factor: 5.422
View more
  5 in total

1.  The 'calcium sensitising' effects of ORG30029 in saponin- or Triton-skinned rat cardiac muscle.

Authors:  D J Miller; D S Steele
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

2.  Nitric oxide enhances 12-HETE versus LTB4 generation in pancreatic transplantation.

Authors:  G Hotter; D Closa; F Pí; L Fernández-Cruz; E Gelpí; J Roselló-Catafau
Journal:  Inflammation       Date:  1996-02       Impact factor: 4.092

3.  Cytotoxic enzyme release and oxygen centered radical formation in human neutrophils are selectively inhibited by E-type prostaglandins but not by PGI2.

Authors:  G Hecker; P Ney; K Schrör
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

4.  Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro.

Authors:  M Villanueva; R Heckenberger; H Strobach; M Palmér; K Schrör
Journal:  Br J Clin Pharmacol       Date:  1993-03       Impact factor: 4.335

5.  Characterization of prostanoid receptors on rat neutrophils.

Authors:  H Wise; R L Jones
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.