| Literature DB >> 24664754 |
Vera L Bonilha1, Mary E Rayborn, Xiaoping Yang, Chengsong Xie, Huaibin Cai.
Abstract
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.Entities:
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Year: 2014 PMID: 24664754 PMCID: PMC5884105 DOI: 10.1007/978-1-4614-3209-8_81
Source DB: PubMed Journal: Adv Exp Med Biol ISSN: 0065-2598 Impact factor: 2.622