| Literature DB >> 24664723 |
Hong Hao1, Janina Gregorski, Haohua Qian, Yichao Li, Chun Y Gao, Sana Idrees, Bin Zhang.
Abstract
LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1 (- / -) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1 (- / -) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis.Entities:
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Year: 2014 PMID： 24664723 PMCID： PMC4446970 DOI： 10.1007/978-1-4614-3209-8_50
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622