Literature DB >> 24664692

What is the nature of the RGC-5 cell line?

C Sippl1, E R Tamm.   

Abstract

The immortalized RGC-5 cell line has been widely used as a cell culture model to study the neurobiology of retinal ganglion cells (RGCs). The cells were originally introduced as derived from rat RGC showing expression of various neuronal markers, in particular the RGC-characteristic proteins Brn3 and Thy1. Recent data gave rise to concerns regarding the origin and nature of the cells. RGC-5 cells were identified to be of mouse origin and their expression of RGC characteristics was questioned by some laboratories. This article summarizes the available data on the properties of RGC-5, discusses common protocols for their differentiation and is aimed at providing researchers some guidelines on the benefits and limitations of RGC-5 for research.

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Year:  2014        PMID： 24664692     DOI： 10.1007/978-1-4614-3209-8_19

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  16 in total

1.  Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy.

Authors:  Wenjun Wang; Qing Wang; Danyang Wan; Yue Sun; Lin Wang; Hong Chen; Chengyu Liu; Robert B Petersen; Jianshuang Li; Weili Xue; Ling Zheng; Kun Huang
Journal:  Autophagy       Date:  2017-03-02       Impact factor: 16.016

2.  Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration.

Authors:  Yue Sun; Weili Xue; Zhiyin Song; Kun Huang; Ling Zheng
Journal:  J Mol Med (Berl)       Date:  2015-11-04       Impact factor: 4.599

Review 3.  Primary retinal cultures as a tool for modeling diabetic retinopathy: an overview.

Authors:  Andrea Matteucci; Monica Varano; Cinzia Mallozzi; Lucia Gaddini; Marika Villa; Sara Gabrielli; Giuseppe Formisano; Flavia Pricci; Fiorella Malchiodi-Albedi
Journal:  Biomed Res Int       Date:  2015-01-19       Impact factor: 3.411

4.  Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway.

Authors:  Katharina Bell; Corina Wilding; Sebastian Funke; Norbert Pfeiffer; Franz H Grus
Journal:  BMC Ophthalmol       Date:  2015-06-27       Impact factor: 2.209

5.  A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.

Authors:  Kapil Sirohi; Asha Kumari; Vegesna Radha; Ghanshyam Swarup
Journal:  PLoS One       Date:  2015-09-16       Impact factor: 3.240

6.  The neuroprotective effect of maltol against oxidative stress on rat retinal neuronal cells.

Authors:  Yookyung Song; Samin Hong; Yoko Iizuka; Chan Yun Kim; Gong Je Seong
Journal:  Korean J Ophthalmol       Date:  2015-01-22

7.  The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2).

Authors:  George Taylor-Walker; Savannah A Lynn; Eloise Keeling; Rosie Munday; David A Johnston; Anton Page; Jennifer A Scott; Srini Goverdhan; Andrew J Lotery; J Arjuna Ratnayaka
Journal:  Exp Eye Res       Date:  2016-10-15       Impact factor: 3.467

8.  661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.

Authors:  Zuberwasim Sayyad; Kapil Sirohi; Vegesna Radha; Ghanshyam Swarup
Journal:  Sci Rep       Date:  2017-12-04       Impact factor: 4.379

9.  Protective effect of mitochondria‑targeted peptide MTP‑131 against oxidative stress‑induced apoptosis in RGC‑5 cells.

Authors:  Min Chen; Bingqian Liu; Jian Ma; Jian Ge; Kaijun Wang
Journal:  Mol Med Rep       Date:  2017-03-01       Impact factor: 2.952

10.  Inhibition on Apoptosis Induced by Elevated Hydrostatic Pressure in Retinal Ganglion Cell-5 via Laminin Upregulating β1-integrin/Focal Adhesion Kinase/Protein Kinase B Signaling Pathway.

Authors:  Yi Li; Yan-Ming Chen; Ming-Ming Sun; Xiao-Dan Guo; Ya-Chen Wang; Zhong-Zhi Zhang
Journal:  Chin Med J (Engl)       Date:  2016-04-20       Impact factor: 2.628
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