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Literature DB >> 24664146

A gold-catalysed imine-propargylamine cascade sequence: synthesis of 3-substituted-2,5-dimethylpyrazines and the reaction mechanism.

Benito Alcaide¹, Pedro Almendros, José M Alonso, Israel Fernández, Gonzalo Gómez-Campillos, M Rosario Torres.

Abstract

The gold-catalysed coupling reaction between propargylamine-derived imines and propargylamine exclusively afforded pyrazines. Besides, in order to understand the mechanism of this sequence, deuterium labeling and computational studies have been performed.

Entities: Chemical

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Year: 2014 PMID： 24664146 DOI： 10.1039/c4cc01485e

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

2 in total

1. Au(I)-catalyzed annulation of propargyl amine with aldehydes: one-pot cascade synthesis of 2,5-dimethylpyrazines.

Authors: Ji Su; Huixin Liu; Ruimao Hua
Journal: Int J Mol Sci Date: 2015-02-05 Impact factor: 5.923

Review 2. Metal-free multicomponent approach for the synthesis of propargylamine: a review.

Authors: Sujit Ghosh; Kinkar Biswas
Journal: RSC Adv Date: 2021-01-07 Impact factor: 3.361

2 in total