B G Wallin1, T Karlsson1, G Pegenius1, A-K Karlsson2, V G Macefield3, M Elam1. 1. Department of Clinical Neurophysiology, Institute of Neuroscience and Physiology, Sahlgren Academy at University of Gothenburg, Sahlgren University Hospital, Gothenburg, Sweden. 2. Department of Neurology, Institute of Neuroscience and Physiology, Sahlgren Academy at University of Gothenburg, Gothenburg, Sweden. 3. School of Medicine, University of Western Sydney, Sydney, NSW, Australia.
Abstract
STUDY DESIGN: Clinical experimental mechanistic study. OBJECTIVES: (1) To determine in three spinal cord-injured patients whether individual muscle sympathetic nerve fibres below the level of the spinal lesion display spontaneous activity. (2) To determine in these patients if individual sympathetic vasoconstrictor fibres show a prolonged discharge following a bladder stimulus. SETTING: University hospital in Gothenburg, Sweden. METHODS: Microneurographic recordings of action potentials from individual muscle nerve sympathetic fibres in a peroneal nerve. Recordings of skin blood flow and electrodermal responses in a foot. RESULTS: In all patients, there was sparse ongoing spontaneous impulse traffic in individual sympathetic fibres. Brisk mechanical pressure over the urinary bladder evoked a varying number of action potentials in individual fibres, but the activity was brief and did not continue after the end of the evoked multiunit burst. CONCLUSION: Prolonged discharges in individual sympathetic fibres are unlikely to contribute to a long duration of blood pressure increases induced by brief bladder stimuli.
STUDY DESIGN: Clinical experimental mechanistic study. OBJECTIVES: (1) To determine in three spinal cord-injuredpatients whether individual muscle sympathetic nerve fibres below the level of the spinal lesion display spontaneous activity. (2) To determine in these patients if individual sympathetic vasoconstrictor fibres show a prolonged discharge following a bladder stimulus. SETTING: University hospital in Gothenburg, Sweden. METHODS: Microneurographic recordings of action potentials from individual muscle nerve sympathetic fibres in a peroneal nerve. Recordings of skin blood flow and electrodermal responses in a foot. RESULTS: In all patients, there was sparse ongoing spontaneous impulse traffic in individual sympathetic fibres. Brisk mechanical pressure over the urinary bladder evoked a varying number of action potentials in individual fibres, but the activity was brief and did not continue after the end of the evoked multiunit burst. CONCLUSION: Prolonged discharges in individual sympathetic fibres are unlikely to contribute to a long duration of blood pressure increases induced by brief bladder stimuli.
Authors: Emma C Hart; Geoffrey A Head; Jason R Carter; B Gunnar Wallin; Clive N May; Shereen M Hamza; John E Hall; Nisha Charkoudian; John W Osborn Journal: Am J Physiol Heart Circ Physiol Date: 2017-03-31 Impact factor: 4.733
Authors: Matthieu Gautier; Lois Mahe; Jan Elaine Soriano; Andreas Rowald; Jordan W Squair; Arnaud Bichat; Newton Cho; Mark A Anderson; Nicholas D James; Jerome Gandar; Anthony V Incognito; Giuseppe Schiavone; Zoe K Sarafis; Achilleas Laskaratos; Kay Bartholdi; Robin Demesmaeker; Salif Komi; Charlotte Moerman; Bita Vaseghi; Berkeley Scott; Ryan Rosentreter; Claudia Kathe; Jimmy Ravier; Laura McCracken; Xiaoyang Kang; Nicolas Vachicouras; Florian Fallegger; Ileana Jelescu; YunLong Cheng; Qin Li; Rik Buschman; Nicolas Buse; Tim Denison; Sean Dukelow; Rebecca Charbonneau; Ian Rigby; Steven K Boyd; Philip J Millar; Eduardo Martin Moraud; Marco Capogrosso; Fabien B Wagner; Quentin Barraud; Erwan Bezard; Stéphanie P Lacour; Jocelyne Bloch; Grégoire Courtine; Aaron A Phillips Journal: Nature Date: 2021-01-27 Impact factor: 49.962