Hector M García-García1, Takashi Muramatsu2, Shimpei Nakatani3, Il Soo Lee2, Niels Ramsing Holm4, Leif Thuesen4, Robert-Jan van Geuns2, Martin van der Ent5, Vladimir Borovicanin6, Dragica Paunovic6, Yoshinobu Onuma2, Patrick W Serruys2. 1. Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Cardialysis B.V., Rotterdam, The Netherlands hect2701@gmail.com hgarcia@cardialysis.nl hect2701@yahoo.es. 2. Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. 3. Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Cardialysis B.V., Rotterdam, The Netherlands Aarhus University Hospital, Skejby 8200, Denmark Maasstad ziekenhuis, Rotterdam 3079 DZ, The Netherland Terumo Europe, Leuven, Belgium. 4. Aarhus University Hospital, Skejby 8200, Denmark. 5. Maasstad ziekenhuis, Rotterdam 3079 DZ, The Netherland. 6. Terumo Europe, Leuven, Belgium.
Abstract
AIMS: To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. METHODS AND RESULTS: In a multi-centre study, 141 patients with ST elevation myocardial infarction <12 h from onset were randomized to either PPCI with thrombectomy (TB) using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70). OFDI after drug-eluting stenting was performed using TERUMO OFDI system. Per protocol, at follow-up 49 patients segments were reimaged. At post-procedure and follow-up, there were no differences in stent and lumen areas between the two groups. At follow-up, per strut-level analysis, percentage of incompletely apposed struts was 0.42 ± 0.94 vs. 0.38 ± 0.77% (P = 0.76), and percentage of covered struts was 92.7 ± 7.2 vs. 94.4 ± 9.2% (P = 0.47) in the TB and non-TB groups, respectively. There was a positive correlation between intra-stent structure (ISS) volume at post-procedure and the neointima volume at 6-month follow-up (Pearson's r = 0.409, P = 0.04). Up to 12 months, there have been two and four patients having target vessel failure in the TB and in the non-TB groups, respectively. CONCLUSIONS: In patients with STEMI, there were no significant differences in OFDI parameters between TB and non-TB groups at both post-procedure and 6-month follow-up. However, ISS volume at post-procedure was positively associated with neointimal volume at 6-month follow-up. Published on behalf of the European Society of Cardiology. All rights reserved.
RCT Entities:
AIMS: To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. METHODS AND RESULTS: In a multi-centre study, 141 patients with ST elevation myocardial infarction <12 h from onset were randomized to either PPCI with thrombectomy (TB) using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70). OFDI after drug-eluting stenting was performed using TERUMO OFDI system. Per protocol, at follow-up 49 patients segments were reimaged. At post-procedure and follow-up, there were no differences in stent and lumen areas between the two groups. At follow-up, per strut-level analysis, percentage of incompletely apposed struts was 0.42 ± 0.94 vs. 0.38 ± 0.77% (P = 0.76), and percentage of covered struts was 92.7 ± 7.2 vs. 94.4 ± 9.2% (P = 0.47) in the TB and non-TB groups, respectively. There was a positive correlation between intra-stent structure (ISS) volume at post-procedure and the neointima volume at 6-month follow-up (Pearson's r = 0.409, P = 0.04). Up to 12 months, there have been two and four patients having target vessel failure in the TB and in the non-TB groups, respectively. CONCLUSIONS: In patients with STEMI, there were no significant differences in OFDI parameters between TB and non-TB groups at both post-procedure and 6-month follow-up. However, ISS volume at post-procedure was positively associated with neointimal volume at 6-month follow-up. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Manel Sabaté; Stephan Windecker; Andres Iñiguez; Lisette Okkels-Jensen; Angel Cequier; Salvatore Brugaletta; Sjoerd H Hofma; Lorenz Räber; Evald Høi Christiansen; Maarten Suttorp; Thomas Pilgrim; Gerrit Anne van Es; Yohei Sotomi; Hector M García-García; Yoshinobu Onuma; Patrick W Serruys Journal: Eur Heart J Date: 2015-09-23 Impact factor: 29.983
Authors: Regina El Dib; Frederick Alan Spencer; Erica Aranha Suzumura; Huda Gomaa; Joey Kwong; Gordon Henry Guyatt; Per Olav Vandvik Journal: BMC Cardiovasc Disord Date: 2016-06-02 Impact factor: 2.298