| Literature DB >> 24662368 |
D Borsook1, N Erpelding2, A Lebel3, C Linnman4, R Veggeberg2, P E Grant5, C Buettner6, L Becerra4, R Burstein7.
Abstract
The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.Entities:
Keywords: Allostatic load; Cortical spreading depression; Estrogen; Gonadotrophins; Headache; Hypothalamus; Menstrual cycle; Pain; Progesterone; Puberty; Sleep; Trigeminal; Women
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Year: 2014 PMID： 24662368 PMCID： PMC4171725 DOI： 10.1016/j.nbd.2014.03.008
Source DB: PubMed Journal: Neurobiol Dis ISSN： 0969-9961 Impact factor: 5.996