Mark Obermann 1 , Sebastian Wurthmann 2 , Benedict Schulte Steinberg 2 , Nina Theysohn 3 , Hans-Christoph Diener 2 , Steffen Naegel 2 Show Affiliations »
Abstract
BACKGROUND: Vestibular migraine affects 1% of the general population, and 30%-50% of all migraine patients describe occasionally associated vertigo or dizziness. We aimed to identify brain regions altered in vestibular migraine in order to evaluate the connection between migraine and the vestibular system. METHODS: Seventeen patients with definite vestibular migraine were compared to 17 controls using magnetic resonance imaging-based voxel-based morphometry. RESULTS: We found grey matter (GM) volume reduction in the superior, inferior and middle (MT/V5) temporal gyrus as well as in the mid. cingulate, dorsolateral prefontal, insula, parietal and occipital cortex. A negative correlation of disease duration and GM volume was observed in areas associated with pain and vestibular processing. Moreover, there was a negative correlation between headache severity and prefrontal cortex volume. CONCLUSION: Alterations identified in vestibular migraine resemble those previously described for migraine, but also extend to areas involved in multisensory vestibular control and central vestibular compensation possibly representing the pathoanatomic connection between migraine and the vestibular system. © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
BACKGROUND: Vestibular migraine affects 1% of the general population, and 30%-50% of all migraine patients describe occasionally associated vertigo or dizziness . We aimed to identify brain regions altered in vestibular migraine in order to evaluate the connection between migraine and the vestibular system. METHODS: Seventeen patients with definite vestibular migraine were compared to 17 controls using magnetic resonance imaging-based voxel-based morphometry. RESULTS: We found grey matter (GM) volume reduction in the superior, inferior and middle (MT/V5) temporal gyrus as well as in the mid. cingulate, dorsolateral prefontal, insula, parietal and occipital cortex. A negative correlation of disease duration and GM volume was observed in areas associated with pain and vestibular processing. Moreover, there was a negative correlation between headache severity and prefrontal cortex volume. CONCLUSION: Alterations identified in vestibular migraine resemble those previously described for migraine , but also extend to areas involved in multisensory vestibular control and central vestibular compensation possibly representing the pathoanatomic connection between migraine and the vestibular system. © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Entities: Disease
Species
Keywords:
Voxel-based morphometry; dizziness; migraine; neuronal plasticity; pain processing; vertigo; vestibular migraine
Mesh： See more »
Year: 2014
PMID： 24662323 DOI： 10.1177/0333102414527650
Source DB: PubMed Journal: Cephalalgia ISSN： 0333-1024 Impact factor: 6.292