AIM: We investigated monocyte and macrophage death and cytokine production induced by amorphous silica nanoparticles (SiO2-NPs) to clarify the role of defined serum corona proteins. MATERIALS & METHODS: The cytotoxic proinflammatory effects of SiO2-NPs on human monocytes and macrophages were characterized in no serum, in fetal calf serum and in the presence of purified corona proteins. RESULTS: In no serum and in fetal calf serum above approximately 75 µg/ml, SiO2-NPs lysed monocytes and macrophages by plasma membrane damage (necrosis). In fetal calf serum below approximately 75 µg/ml, SiO2-NPs triggered an endolysosomal acidification and caspase-1-dependent monocyte death (pyroptosis). The corona high-density lipoproteins:albumin ratio accounted for the features of the SiO2-NPs in serum. DISCUSSION: Corona high-density lipoproteins are a major determinant of the differential cytotoxic action of SiO2-NPs on monocytes and macrophages.
AIM: We investigated monocyte and macrophage death and cytokine production induced by amorphous silica nanoparticles (SiO2-NPs) to clarify the role of defined serum corona proteins. MATERIALS & METHODS: The cytotoxic proinflammatory effects of SiO2-NPs on human monocytes and macrophages were characterized in no serum, in fetal calf serum and in the presence of purified corona proteins. RESULTS: In no serum and in fetal calf serum above approximately 75 µg/ml, SiO2-NPs lysed monocytes and macrophages by plasma membrane damage (necrosis). In fetal calf serum below approximately 75 µg/ml, SiO2-NPs triggered an endolysosomal acidification and caspase-1-dependent monocyte death (pyroptosis). The corona high-density lipoproteins:albumin ratio accounted for the features of the SiO2-NPs in serum. DISCUSSION: Corona high-density lipoproteins are a major determinant of the differential cytotoxic action of SiO2-NPs on monocytes and macrophages.
Authors: Massimiliano Bianchi; Martina Chiu; Giuseppe Taurino; Roberta Ruotolo; Nelson Marmiroli; Enrico Bergamaschi; Francesco Cubadda; Ovidio Bussolati Journal: Nanomaterials (Basel) Date: 2020-07-18 Impact factor: 5.076
Authors: Duong N Trinh; Meda Radlinskaite; Jack Cheeseman; Gunter Kuhnle; Helen M I Osborn; Paula Meleady; Daniel I R Spencer; Marco P Monopoli Journal: Nanomaterials (Basel) Date: 2022-08-03 Impact factor: 5.719
Authors: Khaled S Allemailem; Ahmad Almatroudi; Faris Alrumaihi; Saleh A Almatroodi; Mohammad O Alkurbi; Ghaiyda Talal Basfar; Arshad Husain Rahmani; Amjad Ali Khan Journal: Int J Nanomedicine Date: 2021-07-26
Authors: Lizhen Jiang; Yongbo Yu; Yang Li; Yang Yu; Junchao Duan; Yang Zou; Qiuling Li; Zhiwei Sun Journal: Nanoscale Res Lett Date: 2016-02-02 Impact factor: 4.703